Anti-Human CDH1 Recombinant Antibody (hSC10.17) (CAT#: TAB-1411CL)

Figure 1 illustrating that CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin, and the EC50 (e.g., half-maximal effective concentration) was determined for selected modulators.

Figure 2 is a graphical representation demonstrating that the disclosed CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to various patient-derived non-traditional xenograft cells expressing CD324 wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin.

Figure 3 illustrates the ability of the disclosed modulators to inhibit CD324 homotypic binding.

Figure 4 demonstrates that humanized CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin and where the determined EC50 (e.g., half-maximal effective concentration) values are indicative of efficient cell killing.