Mouse Anti-CLDN4 Recombinant Antibody (clone PT1925) (CAT#: VS3-CJ120)
This product is a mouse antibody that recognizes CLDN4.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/if_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_7_5.jpg
Figure 3 Esophagus
(Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_6_1.jpg
(Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_6_1.jpg
Figure 4 High expression in colon.
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_7_3.jpg
Figure 5 Kidney
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_8_5.jpg
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189143-CLDN4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189143-CLDN4
Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 4
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human CLDN4
- Species Reactivity
- Human
- Clone
- PT1925
- Applications
- WB, IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:2000), Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
- Gene ID
- 1364
- UniProt ID
- O14493
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane
- Post Translation Modifications
- Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
- Protein Refseq
- NP_001296.1
- Function
- Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "CLDN4"
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IgG Antibody Products
Mouse Antibody Products
Chimeric Antibody Products
Humanized Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3288z | Mouse Anti-CLDN4 Recombinant Antibody (clone 38H5) | IHC, IF, WB | Mouse IgG1 |
| ZG-0160J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0160J) | IHC-P, IF | Mouse IgG |
| ZG-0161J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0161J) | IHC-P, IF | Mouse IgG |
| ZG-0618J | Rabbit Anti-CLDN4 Recombinant Antibody (clone 2G12) | ELISA | Rabbit IgG |
| VS4-WK113 | Human Anti-CLDN4 Recombinant Antibody (clone 8G7) | ELISA | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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