Mouse Anti-COL3A1 Recombinant Antibody (VS3-CJ286) (CAT#: VS3-CJ286)

• Immunogen
• KLH-conjugated synthetic peptide encompassing a sequence of human Collagen 3 alpha 1

• Host Species
• Mouse

• Specificity
• Human, Mouse and Rat COL3A1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC

• Conjugate
• Unconjugated

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 30% Glycerol, 0.87% NaCl, 0.42% Potassium phosphate, pH7.3.

• Preservative
• 0.01% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• This antibody has been tested for use in Western Blot (1:1000-1:2000), Immunohistochemistry (1:200-1:500).

• Alternative Names
• Collagen alpha-1(III) chain; EDS4A; EDSVASC

• Gene ID
• 1281

• UniProt ID
• P02461

• Sequence Similarities
• Belongs to the fibrillar collagen family.

• Cellular Localization
• Extracellular matrix, Secreted

• Post Translation Modifications
• Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

• Protein Refseq
• NP_000081.1

• Function
• Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

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