Anti-COL3A1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your vascular biology and fibrosis research partner, providing you with premium anti-COL3A1 recombinant antibodies. Collagen Type III (COL3A1), the main structural protein of reticular fibers, is the building block of the connective tissues of all hollow organs and tissues that are inherently stretchable, such as the skin, blood vessels, lungs, uterus and the intestines. Our top-grade and highly specific antibodies are perfect for studying the pathology of vascular Ehlers-Danlos syndrome, as well as the role of COL3A1 in wound healing and tissue fibrosis.

COL3A1: The Collagen of Distensible Tissues

Collagen Type III Alpha 1 (COL3A1) is a fibrillar collagen that is abundant in hollow organs and distensible tissues. It is found co-localized with the fibril-forming collagen Type I, but it forms thinner, more elastic reticular fibers to provide structural support to tissues such as the uterus, lungs, and intestines, and above all, the wall of the arteries. Mutations in the COL3A1 gene result in the life-threatening vascular form of Ehlers-Danlos syndrome (vEDS) characterized by increased risk of catastrophic arterial or organ rupture. As with COL1A1, this collagen is also overproduced during the fibrotic response.

Alternative Names

EDS4A; EDSVASC; PMGEDSV; collagen alpha-1(III) chain; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha-1 type III collagen; alpha1 (III) collagen; collagen, fetal; collagen, type III, alpha 1

Background

COL3A1 (Collagen Type III Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL3A1 include Ehlers-Danlos Syndrome, Vascular Type and Acrogeria, Gottron Type. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include integrin binding and SMAD binding. An important paralog of this gene is COL2A1.

Anti-COL3A1 rAb Products

The recombinant antibodies to COL3A1 available from Creative Biolabs are engineered for high specificity and validated to reliably detect the Type III collagen, without cross-reactivity with the other abundant collagens. Optimized for IHC on tissue sections to map its distribution, as well as for Western Blot of cell lysates, our rAbs are also the ideal tool for any research into COL3A1 biology in the context of vascular biology and fibrosis.

Table 1. Featured anti-COL3A1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs prides itself on its unwavering commitment to quality. The production of our anti-COL3A1 recombinant antibodies is carried out in a quality-assured environment, each lot of reagent validated for purity and specificity, and reliable performance in established applications so you know you’re getting a top-performing reagent that will give you high-integrity data.

Customer Reviews

rAb Production

Creative Biolabs is a leader in recombinant antibody technology. Our anti-COL3A1 recombinant antibodies are produced in state-of-the-art systems optimized to ensure the highest quality, as well as that they accurately recognize the native protein, so that you are getting a specific and active research tool.

Featured Anti-COL3A1 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-COL3A1 recombinant antibody production.

Fig.4 Gram-scale anti-COL3A1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting research with innovative and flexible solutions. Our anti-COL3A1 recombinant antibodies are available in multiple customizable modalities to provide you with the most useful tools for your research.

Fig.5 Full-length anti-COL3A1 recombinant antibody production and modalities.

Decode the role of COL3A1 in tissue integrity with Creative Biolabs’ superior recombinant antibodies. Validated to the highest standard, and with unparalleled specificity, this portfolio provides the perfect tools for your vascular disease and fibrosis research. Trust Creative Biolabs and get your next research breakthroughs to the finish line. Contact our experts today.