Rabbit Anti-CTNND1 Recombinant Antibody (VS3-FY2680) (CAT#: VS3-FY2680)
The anti-CTNND1 antibody has been genetically engineered to specifically target human delta 1 Catenin protein. It shows capability of cross-reacting with mouse and rat. This monoclonal antibody proves valuable in disease research related to Blepharocheilodontic Syndrome 2 and Blepharocheilodontic Syndrome 1.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3837/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3837/if_selected.jpg
Figure 3 Small intestine
(High expression in small intestine)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15954/ihc_selected.jpg
(High expression in small intestine)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15954/ihc_selected.jpg
Figure 4 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_6_2_selected.jpg
(Immunohistochemical staining of human small intestine shows cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_6_2_selected.jpg
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_7_4.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_9_8.jpg
Figure 7 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15955/36069_A_7_3.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198561-CTNND1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198561-CTNND1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Catenin delta 1 of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC, IP
- Conjugate
- Unconjugated, FITC
- Related Disease
- Blepharocheilodontic Syndrome 2 and Blepharocheilodontic Syndrome 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Catenin Delta 1; Catenin (Cadherin-Associated Protein), Delta 1; Cadherin-Associated Src Substrate; P120 Catenin; P120(CAS); P120(CTN); CAS; Catenin Delta-1
- Gene ID
- 1500
- UniProt ID
- O60716
- Sequence Similarities
- Belongs to the beta-catenin family.
- Cellular Localization
- Cell junction, adherens junction
Cytoplasm
Nucleus
Cell membrane
- Post Translation Modifications
- Phosphorylated by FER and other protein-tyrosine kinases.
Phosphorylated at Ser-288 by PAK5.
Dephosphorylated by PTPRJ.
Glycosylation at Asn641
Ubiquitination at Lys710
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001078927.1; NP_001078928.1; NP_001078929.1; NP_001078930.1; NP_001078931.1
- Function
- Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, 20371349).
Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3971z | Mouse Anti-CTNND1 Recombinant Antibody (clone 43H7) | WB, IP, IF | Mouse IgG1, κ |
| VS3-CJ159 | Mouse Anti-CTNND1 Recombinant Antibody (VS3-CJ159) | WB, IHC | Mouse IgG |
| VS3-WK1986 | Rabbit Anti-CTNND1 (pY228) Recombinant Antibody (clone R08-5A8) | WB, ICC, IF, IP | Rabbit IgG |
| VS3-WK2022 | Rabbit Anti-CTNND1 (pS268) Recombinant Antibody (clone R06-0H8) | WB | Rabbit IgG |
| VS3-WK2023 | Rabbit Anti-CTNND1 (pT916) Recombinant Antibody (clone R07-5A6) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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