Rabbit Anti-CTSD Recombinant Antibody (VS13-YC271)
CAT#: VS13-YC271
The Rabbit Anti-CTSD Recombinant Antibody is specific for human and mouse CTSD. CTSD, cathepsin D, affects metabolic and immune pathways, associated with neuronal and metabolic disorders through protease interactions. The anti-CTSD antibody can be used for Western blot (1/500-1/2000), Immunocytochemistry (1/100-1/500), Immunohistochemistry-paraffin (1/100-1/500).
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_B_8_5.jpg
Normal Tissue
Figure 2 Lung
Macrophages
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_2_4.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: Medium
Intensity: Moderate
Enterocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
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Specifications
- Immunogen
- Recombinant human Cathepsin D, aa 363-412.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse CTSD
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IHC-P, IP
- Conjugate
- NONE
- Related Disease
- Ceroid Lipofuscinosis, Neuronal, and Neuronal Ceroid Lipofuscinosis
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunocytochemistry (ICC): 1/100-1/500
Immunohistochemistry-paraffin (IHC-P): 1/100-1/500
Target
- Alternative Names
- Cathepsin D; Ceroid-Lipofuscinosis, Neuronal 10; EC 3.4.23.5; CPSD; Epididymis Secretory Sperm Binding Protein Li 130P; Cathepsin D (Lysosomal Aspartyl Protease);
- Gene ID
- 1509
- UniProt ID
- P07339
- Long Name
- Cathepsin D
- Cellular Localization
- Secreted; Lysosome; Melanosome
- Protein Refseq
- NP_001900.1
- Function
- Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CTSD"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1052 | Mouse Anti-CTSD Recombinant Antibody (clone YC031); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0399-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0399-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
| HPAB-0400-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0400-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0867 | Hi-Affi™ Rabbit Anti-CTSD Recombinant Antibody (clone DS867AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0399-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0399-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
| HPAB-0400-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0400-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX302 | Mouse Anti-CTSD Recombinant Antibody (clone 892CT11.1.1) | WB, IHC | Mouse IgG1 |
| VS3-QX303 | Mouse Anti-CTSD Recombinant Antibody (clone 13F3) | WB, IHC | Mouse IgG1 |
| VS3-QX304 | Mouse Anti-CTSD Recombinant Antibody (clone 13F4) | WB, IHC | Mouse IgG2b |
| VS-0923-FY29 | Recombinant Mouse Anti-CTSD Antibody (VS-0923-FY29) | ELISA, IHC | Mouse IgG1 |
| VS-0923-FY30 | Recombinant Mouse Anti-CTSD Antibody (VS-0923-FY30) | ELISA, WB, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY74 | AbPlus™ Anti-CTSD Magnetic Beads (VS-0424-XY74) | IP, Protein Purification | |
| VS-0724-YC901 | AbPlus™ Anti-Ctsd Magnetic Beads (VS-0724-YC901) | IP, Protein Purification | |
| VS-0724-YC1036 | AbPlus™ Anti-CTSD Magnetic Beads (VS-0724-YC1036) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1782 | Anti-CTSD Immunohistochemistry Kit | IHC | |
| VS-0525-XY1783 | Anti-Mouse CTSD Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC79 | Recombinant Anti-CTSD Eliminating Antibody, pH-Sensitive (VS-0625-YC79) | Antigen-Sweeping In Vivo. | Human IgG1 lambda |
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