Anti-CTSD Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs has established itself as a frontrunner in neurobiology and oncology research, providing premium anti-CTSD recombinant antibodies. As a prominent lysosomal aspartyl protease, Cathepsin D (CTSD) has a multifaceted role in protein catabolism and is closely linked to numerous pathologies. The availability of high-quality antibodies to this target is essential for studying its involvement in cancer progression, neurodegenerative diseases like Alzheimer’s, and the basic mechanisms of lysosomal function.

CTSD: A Key Protease in Lysosomal Function and Disease

Cathepsin D (CTSD) is a soluble aspartyl protease that is widely expressed in lysosomes. CTSD is involved in intracellular and endocytosed protein degradation and is synthesized as an inactive pro-enzyme. In the acidic milieu of the lysosome, it undergoes proteolytic processing to its active form. While CTSD is essential for lysosomal housekeeping, it is also increasingly implicated in disease pathology. For example, in cancer, it is overexpressed and secreted by tumor cells, promoting tumor growth and metastasis. In addition, CTSD is involved in amyloid precursor protein processing and may therefore contribute to Alzheimer’s disease pathology.

Alternative Names

Cathepsin D; EC 3.4.23.5; CPSD; Epididymis Secretory Sperm Binding Protein Li 130P; Cathepsin D (Lysosomal Aspartyl Protease); Ceroid-Lipofuscinosis, Neuronal 10; Lysosomal Aspartyl Peptidase; Lysosomal Aspartyl Protease; Ceroid-Lipofuscinosis; Neuronal 10; HEL-S-130P; EC 3.4.23; CLN10

Background

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Anti-CTSD rAb Products

Creative Biolabs’ anti-CTSD recombinant antibodies are designed for optimal specificity and performance. They have been thoroughly validated to detect all forms of the enzyme, including the pro-enzyme and the mature heavy/light chains. Optimized for a range of applications, including IHC to study subcellular localization and Western Blot to study processing and expression, our rAbs are the ultimate tools to study this target in your biology.

Table 1. Featured anti-CTSD recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

B**le

We use this antibody to monitor the processing of the pro-Cathepsin D to the mature enzyme by Western blot. The signal is highly specific and we have found it has been very useful for our work on lysosomal maturation.

11/Oct/2024

rAb Production

Creative Biolabs is proud to utilize the latest technology in recombinant antibody production to expedite discovery in cell biology. Anti-CTSD recombinant antibodies are engineered to provide the highest specificity and sensitivity to this lysosomal protease.

Featured Anti-CTSD Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CTSD recombinant antibody production.

Fig.2 Gram-scale anti-CTSD recombinant antibody production.

rAb Modalities

Creative Biolabs is always focused on delivering the most flexible and innovative solutions to our research community. Our anti-CTSD antibodies come in a wide variety of formats to help you design your experiments to study this important protease in a variety of ways.

Fig.3 Full-length anti-CTSD recombinant antibody production and modalities.

Superior anti-CTSD recombinant antibodies for use in drug discovery or basic cell biology from Creative Biolabs. Defined by exceptional specificity and extensive validation, our products are the ideal tools for your research. Let our experts help you today.