Human Anti-CXCL12 Recombinant Antibody (HPAB-633-FY) (CAT#: HPAB-633-FY)
This product is a recombinant human antibody that is designed to target C-X-C motif chemokine ligand 12. Through its properties, the antibody has demonstrated a notable capacity to inhibit VEGF-induced angiogenesis. Its mechanism potentially involves the obstruction of CXCL12 binding to both CXCR4 and CXCR7, resulting in a heightened efficacy in inhibiting CXCL12-induced angiogenesis. The calculated binding affinity of this antibody to CXCL12 has been determined to be 3.7nM.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_7_5.jpg
Figure 2 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_7_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_7_5.jpg
Figure 3 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_6_6.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_4_4.jpg
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_4_4.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107562-CXCL12
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107562-CXCL12
Specifications
- Host Species
- Human
- Derivation
- Chimeric (Mouse/Human)
- Type
- Chimeric (Mouse/Human) IgG2a
- Specificity
- Human CXCL12
- Species Reactivity
- Human, Mouse
- Applications
- Block
- Related Disease
- Ovarian cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C-X-C Motif Chemokine Ligand 12; Pre-B Cell Growth-Stimulating Factor; Chemokine (C-X-C Motif) Ligand 12; Intercrine Reduced In Hepatomas; Stromal Cell-Derived Factor 1; SDF1; PBSF; IRH; C-X-C Motif Chemokine 12;
- Gene ID
- 6387
- UniProt ID
- P48061
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Single Domain Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256 | Recombinant Anti-human CXCL12 Antibody | ELISA, WB, FC, FuncS | IgG |
| HPAB-0050LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0050LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0051LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0051LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| MRO-1795-CN | Rabbit Anti-CXCL12 Polyclonal Antibody (MRO-1795-CN) | WB, IHC, FC | Rabbit IgG |
| HPAB-632-FY | Human Anti-CXCL12 Recombinant Antibody (HPAB-632-FY) | Inhib | Chimeric (Mouse/Human) IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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