Rabbit Anti-ERBB4 Recombinant Antibody (clone R03-6B4) (CAT#: VS3-XY3349)
This is a primary rabbit antibody recognizing with human ERBB4 (Erb-b2 receptor tyrosine kinase 4), which acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. It also has cross-reactivity against mouse and rat ERBB4. It has been tested using Western Blot, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_5.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_B_8_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_8_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_8_4.jpg
Figure 5 RNA cell line category: Cell line enhanced (AF22, EFO-21, HEK93, RPTEC TERT1, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178568-ERBB4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178568-ERBB4
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ERBB4
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-6B4
- Applications
- WB, ICC, IF, FC, IP
- Related Disease
- Amyotrophic Lateral Sclerosis 19; Amyotrophic Lateral Sclerosis 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- HER4; ALS19; p180erbB4
- Gene ID
- 2066
- UniProt ID
- Q15303
- Long Name
- Erb-b2 receptor tyrosine kinase 4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn138, Asn174, Asn181, Asn253, Asn358, Asn410, Asn473, Asn495, Asn548, Asn576, and Asn620 (NX_Q15303 [NX_Q15303-1])
Ubiquitination at Lys745 and Lys1265 (NX_Q15303 [NX_Q15303-1])
Modification sites at PhosphoSitePlus (Q15303)
Glycosylation from GlyGen (Q15303) 11 sites
- Protein Refseq
- XP_005246433.1; XP_005246434.1
- Function
- Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF.
Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.
Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses.
Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Related Resources
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-470 | Mouse Anti-ERBB4 Recombinant Antibody (PABL-470) | WB, IF, FuncS | Mouse IgG |
| MOB-0689CT | Recombinant Mouse anti-Human ERBB4 Monoclonal antibody (I5.83.9) | FC | |
| VS3-QX383 | Mouse Anti-ERBB4 Recombinant Antibody (clone 1C10E8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-QX384 | Mouse Anti-ERBB4 Recombinant Antibody (clone 4G19) | WB, IP, IF, IHC, FC | Mouse IgG1 |
| VS3-FY513 | Recombinant Rabbit Anti-ERBB4 Antibody (clone R07-2H1) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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