Rabbit Anti-ERBB4 Recombinant Antibody (clone R03-6B4)
CAT#: VS3-XY3349
This is a primary rabbit antibody recognizing with human ERBB4 (Erb-b2 receptor tyrosine kinase 4), which acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. It also has cross-reactivity against mouse and rat ERBB4. It has been tested using Western Blot, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_5.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_8_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, EFO-21, HEK93, RPTEC TERT1, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178568-ERBB4
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ERBB4
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-6B4
- Applications
- WB, ICC, IF, FC, IP
- Related Disease
- Amyotrophic Lateral Sclerosis 19; Amyotrophic Lateral Sclerosis 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- HER4; ALS19; p180erbB4
- Gene ID
- 2066
- UniProt ID
- Q15303
- Long Name
- Erb-b2 receptor tyrosine kinase 4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn138, Asn174, Asn181, Asn253, Asn358, Asn410, Asn473, Asn495, Asn548, Asn576, and Asn620 (NX_Q15303 [NX_Q15303-1])
Ubiquitination at Lys745 and Lys1265 (NX_Q15303 [NX_Q15303-1])
Modification sites at PhosphoSitePlus (Q15303)
Glycosylation from GlyGen (Q15303) 11 sites
- Protein Refseq
- XP_005246433.1; XP_005246434.1
- Function
- Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF.
Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.
Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses.
Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.
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Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ERBB4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-470 | Mouse Anti-ERBB4 Recombinant Antibody (PABL-470) | WB, IF, FuncS | Mouse IgG |
| HPAB-0530YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0530YY) | ELISA | Human IgG1 |
| HPAB-0531YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0531YY) | ELISA | Human IgG1 |
| HPAB-0532YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0532YY) | ELISA | Human IgG1 |
| VS3-FY513 | Recombinant Rabbit Anti-ERBB4 Antibody (clone R07-2H1) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (PFBL-467) | WB, IF, FuncS | Mouse Fab |
| HPAB-0530YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0530YY-F(E)) | ELISA | Human Fab |
| HPAB-0531YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0531YY-F(E)) | ELISA | Human Fab |
| HPAB-0532YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0532YY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (PSBL-467) | WB, IF, FuncS | Mouse scFv |
| HPAB-0530YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0530YY-S(P)) | ELISA | Human scFv |
| HPAB-0531YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0531YY-S(P)) | ELISA | Human scFv |
| HPAB-0532YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0532YY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-073CT | Anti-Human HER4 Recombinant Antibody (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-S(P) | Anti-Human HER4 Recombinant Antibody scFv Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-F(E) | Anti-Human HER4 Recombinant Antibody Fab Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CT | Mouse Anti-ERBB4 Recombinant Antibody (TAB-074CT) | ELISA, Inhibion, WB | Mouse IgG |
| TAB-074CT-S(P) | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (TAB-074CT-S(P)) | ELISA, Inhibion, WB | Mouse scFv |
| TAB-074CT-F(E) | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (TAB-074CT-F(E)) | ELISA, Inhibion, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-743CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL391) | Block | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-744CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL930) | IP, Neut, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1180 | Hi-Affi™ Rabbit Anti-ERBB4 Recombinant Antibody (clone DS1180AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF427 | A*02:01/Human ERBB-4 (VLVKSPNHV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC301 | Recombinant Anti-ERBB4 Vesicular Antibody, EV Displayed (VS-0425-YC301) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2339 | Anti-ERBB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2340 | Anti-Mouse ERBB4 Immunohistochemistry Kit | IHC |
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