Mouse Anti-FASN Recombinant Antibody (VS3-CJ985) (CAT#: VS3-CJ985)

• Immunogen
• KLH-conjugated synthetic peptide between 942-973 amino acids from the Central region of human FASN

• Host Species
• Mouse

• Type
• Mouse IgM

• Specificity
• Human, Mouse FASN (Center)

• Species Reactivity
• Human, Mouse

• Applications
• WB, ICC

• Conjugate
• Unconjugated

• Purification
• Affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• PBS

• Preservative
• 0.09% Sodium Azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• This antibody has been tested for use in Western Blot (1:1000), Immunocytochemistry (1:200).

• Alternative Names
• FAS; OA-519; SDR27X1

• Gene ID
• 2194

• UniProt ID
• P49327

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.

• Protein Refseq
• NP_004095.4

• Function
• Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
  (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.

Secondary Antibody

• 2ND-052CQ
• Goat Anti-Mouse IgM (H&L) Antibody

• 2RD-A1568-YJ
• Rabbit Anti-Mouse IgM Secondary antibody (Clone RM109)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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