Recombinant Human Antibody clone chJAR 1, which is specific to N. meningitidis fHbp. JAR 1 inhibited binding of fH to fHbp and had human complement-mediated bactericidal activity. It inhibited fH binding, had human complement-mediated bactericidal activity.
Figure 1 Inhibition of binding of a fixed concentration (1 µg/ml) of anti-fHbp mAbs to recombinant fHbp as measured by ELISA.
Red triangles: inhibition of binding of mAb502 (IgG2a) by JAR 1 (IgG3). Green circles: Inhibition of binding of JAR 1 by mAb502. Error bars represent ranges in independent assays.
Figure 2 Binding of JAR 1 to yeast clones displaying randomly mutated fHbp on their surface.
A representative clone is positive for binding to JAR 1 (red solid line) and a control anti-fHbp mAb, JAR 5 (blue dashed line).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-070WM | Anti-N. meningitidis fHbp Recombinant Antibody (502) | ELISA, FC, Inhib | |
TAB-070WM-S(P) | Anti-N. meningitidis fHbp Recombinant Antibody scFv Fragment (502) | WB, FC | |
TAB-070WM-F(E) | Anti-N. meningitidis fHbp Recombinant Antibody Fab Fragment (502) | WB, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-841CQ | Recombinant Mouse Anti-fhbP Antibody (JAR5) | ELISA, WB, BL | IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0137CQ | Recombinant Human Anti-fHbp Antibody (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
FAMAB-0138CQ | Recombinant Human Anti-fHbp Antibody (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
FAMAB-0139CQ | Recombinant Mouse Anti-fHbp Antibody (JAR 1) | ELISA, FC, WB, Inhib | Mouse IgG3 |
HPAB-0023-WJ | Recombinant Mouse Anti-fHbp Antibody (JAR41) | ELISA, FC, DB, Inhib | Mouse IgG1 |
HPAB-0766-WJ | Recombinant Mouse Anti-fHbp Antibody (JAR 64) | ELISA | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0136CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 1) | ELISA, FC, Inhib | Chimeric (mouse/human) Fab |
FAMAB-0137CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
FAMAB-0138CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
FAMAB-0139CQ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR 1) | ELISA, FC, Inhib | Mouse Fab |
FAMAB-0140CQ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR 3) | ELISA, WB, BL, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0139CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 1) | ELISA, FC, Inhib | Mouse scFv |
FAMAB-0140CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 3) | ELISA, WB, BL, FC | Mouse scFv |
HPAB-0023-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR41) | ELISA, FC, DB, Inhib | Mouse scFv |
HPAB-0766-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 64) | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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