This product is a mouse monoclonal IgG1 antibody targeting the N-terminal domain of Neisseria meningitidis factor H binding protein (fHbp) variants. This antibody is generated from a human factor H (fH) transgenic BALB/c mouse immunized with a recombinant fHbp ID 1. This antibody is bactericidal when tested in combination with a second non-bactericidal anti-fHbp mAb
Figure 1 Binding of anti-FHbp MAbs to FHbp ID 22 by ELISA.
(B) Binding of MAb JAR 41, which recognizes an epitope in the N-terminal domain of FHbp.
Konar, M., Pajon, R., & Beernink, P. T. (2015). A meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes. Proceedings of the National Academy of Sciences, 112(48), 14823-14828.
Figure 2 Binding of mAbs to live N. meningitidis strains as measured by flow cytometry.
Panel f, thick black line, 50 µg/ml of JAR 41 with wild-type strain M1239 with fHbp in variant group 3; dark shaded area, 5 µg/ml of JAR 41 (lower concentrations of JAR 41 were not tested); blue line, 50 µg/ml of JAR 5 (specific for fHbp variant group 1); Light gray shade area, 50 µg/ml of JAR 41 incubated with M1239 fHbp knock-out mutant.
Vu, D. M., Pajon, R., Reason, D. C., & Granoff, D. M. (2012). A broadly cross-reactive monoclonal antibody against an epitope on the N-terminus of meningococcal fHbp. Scientific reports, 2, 341.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-070WM | Anti-N. meningitidis fHbp Recombinant Antibody (502) | ELISA, FC, Inhib | |
TAB-070WM-S(P) | Anti-N. meningitidis fHbp Recombinant Antibody scFv Fragment (502) | WB, FC | |
TAB-070WM-F(E) | Anti-N. meningitidis fHbp Recombinant Antibody Fab Fragment (502) | WB, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-841CQ | Recombinant Mouse Anti-fhbP Antibody (JAR5) | ELISA, WB, BL | IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0136CQ | Recombinant Human Anti-fHbp Antibody (chJAR 1) | ELISA, FC, Inhib | Chimeric (mouse/human) IgG1 |
FAMAB-0137CQ | Recombinant Human Anti-fHbp Antibody (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
FAMAB-0138CQ | Recombinant Human Anti-fHbp Antibody (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
FAMAB-0139CQ | Recombinant Mouse Anti-fHbp Antibody (JAR 1) | ELISA, FC, WB, Inhib | Mouse IgG3 |
FAMAB-0140CQ | Recombinant Mouse Anti-fHbp Antibody (JAR 3) | ELISA, WB, Block, FC | Mouse IgG3 |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0136CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 1) | ELISA, FC, Inhib | Chimeric (mouse/human) Fab |
FAMAB-0137CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
FAMAB-0138CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
HPAB-0023-WJ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR41) | ELISA, FC, DB, Inhib | Mouse Fab |
HPAB-0766-WJ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR 64) | ELISA, WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0139CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 1) | ELISA, FC, Inhib | Mouse scFv |
FAMAB-0140CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 3) | ELISA, WB, BL, FC | Mouse scFv |
HPAB-0023-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR41) | ELISA, FC, DB, Inhib | Mouse scFv |
HPAB-0766-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 64) | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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