Anti-FLT3 (clone NC7) Recombinant Antibody Coupled Liposome (VS-1024-FY156)
CAT#: VS-1024-FY156
Antibody-conjugated liposomes specifically designed to target FLT3 mutations aim to precisely identify and attack cancerous cell populations associated with acute myeloid leukemia (AML). By delivering anti-cancer drugs directly to these targeted cells, this innovative approach not only enhances the efficacy of treatment but also minimizes damage to healthy cells. As a result, patients with FLT3 mutations can benefit from a more effective therapeutic strategy, potentially leading to improved outcomes in the fight against AML.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47539/1674_A6_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (REH, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122025-FLT3
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More Infomation
Specifications
- Potential Clinical Applications
- Leukaemia
Product Composition
- Clone
- NC7
- Antibody Type
- IgG1, kappa
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody specifically engineered to target FLT3 (Fms-like tyrosine kinase 3), a receptor tyrosine kinase that plays a critical role in hematopoiesis and the proliferation of hematopoietic stem cells. By binding selectively to FLT3, this antibody can facilitate the detection and analysis of this receptor in various biological contexts, including its involvement in certain hematological malignancies, such as acute myeloid leukemia (AML).
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FLT3
- Introduction
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
- Alternative Names
- Fms Related Tyrosine Kinase 3; Stem Cell Tyrosine Kinase 1; Fms-Like Tyrosine Kinase 3; FL Cytokine Receptor; CD135 Antigen; EC 2.7.10.1; CD135; FLK-2; STK1; FLK2
- Full Name
- Fms Related Tyrosine Kinase 3
- Gene ID
- 2322
- UniProt ID
- P36888
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Membrane; Single-pass type I membrane protein, Endoplasmic reticulum lumen
- Post Translation Modifications
- N-glycosylated, contains complex N-glycans with sialic acid.
- Protein Refseq
- XP_011533317.1; XP_011533320.1; XP_016875975.1; XP_016875977.1; XP_047286172.1
- Function
- Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.
Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.
Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.
Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B.
Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B.
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Datasheet
MSDS
COA
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|---|---|---|---|
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| TAB-011CQ-F(E) | Mouse Anti-FLT3 Recombinant Antibody; Fab Fragment (TAB-011CQ-F(E)) | ELISA, FC | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| TAB-012CQ | Human Anti-FLT3 Recombinant Antibody (TAB-012CQ) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
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| TAB-012CQ-F(E) | Human Anti-FLT3 Recombinant Antibody; Fab Fragment (TAB-012CQ-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| TAB-013CQ-F(E) | Human Anti-FLT3 Recombinant Antibody; Fab Fragment (TAB-013CQ-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
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| CAT | Product Name | Application | Type |
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| HPAB-0103-YC-S(P) | Human Anti-FLT3 Recombinant Antibody; scFv Fragment (HPAB-0103-YC-S(P)) | ELISA, Block, FC | Human scFv |
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| CAT | Product Name | Application | Type |
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| HPAB-0103-YC-F(E) | Human Anti-FLT3 Recombinant Antibody; Fab Fragment (HPAB-0103-YC-F(E)) | ELISA, Block, FC | Humanized Fab |
| HPAB-0182CQ-F(E) | Human Anti-FLT3 Recombinant Antibody (clone D4-3); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-0183CQ-F(E) | Human Anti-FLT3 Recombinant Antibody (clone NC7); Fab Fragment | ELISA, Neut | Human Fab |
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