Mouse Anti-GP6 Recombinant Antibody (clone 12A5); Fab Fragment (CAT#: FAMAB-0101JF-F(E))
Recombinant mouse monoclonal antibody specially binds to platelet glycoprotein VI (GPVI). This anti-GPVI antibody 12A5 can be useful in the treatment of immune thrombocytopenic purpura (ITP).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47611/1925_A11_24_cr5cd55a323d93f_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47611/1925_A11_24_cr5cd55a323d93f_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_B_9_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_B_9_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_7_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_6_6.jpg
Figure 7 RNA cell line category: Group enriched (HEL, K-562, U-2 OS)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088053-GP6
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088053-GP6
Specifications
- Immunogen
- GPVI
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human GPVI
- Species Reactivity
- Human
- Clone
- 12A5
- Applications
- WB, ELISA, FuncS
- Related Disease
- Immune thrombocytopenic purpura
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Glycoprotein VI Platelet; Glycoprotein VI (Platelet); Glycoprotein 6; GPVI; Platelet Collagen Recept; Platelet Glycoprotein VI; BDPLT11; GPIV
- Gene ID
- 51206
- UniProt ID
- Q9HCN6
- Function
- Blocking
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003CT | Anti-Human GPVI Recombinant Antibody (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
| TAB-003CT-S(P) | Anti-Human GPVI Recombinant Antibody scFv Fragment (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
| TAB-003CT-F(E) | Anti-Human GPVI Recombinant Antibody Fab Fragment (1C3) | ELISA, Inhibition, FC | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-005CT | Mouse Anti-GP6 Recombinant Antibody (TAB-005CT) | WB, ELISA, Block | Mouse IgG1, κ |
| TAB-005CT-S(P) | Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (TAB-005CT-S(P)) | WB, ELISA, Block | Mouse scFv |
| TAB-005CT-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (TAB-005CT-F(E)) | WB, ELISA, Block | Mouse Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1483 | Hi-Affi™ Rabbit Anti-GP6 Recombinant Antibody (clone DS1483AB) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0002-CN) | FC, WB | Humanized IgG |
| HPAB-0003-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0003-CN) | FC, WB | Humanized IgG |
| HPAB-0133CQ | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4) | ELISA, FC, Inhib, FuncS | Humanized lgG1 |
| FAMAB-0101JF | Mouse Anti-GP6 Recombinant Antibody (clone 12A5) | WB, ELISA, IHC, FC | Mouse IgG |
| VS-0723-WK132 | Human Anti-GP6 Recombinant Antibody (VS-0723-WK132) | FC | Chimeric (rabbit/human) IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN-S(P) | Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0002-CN-S(P)) | FC, WB | Humanized scFv |
| HPAB-0003-CN-S(P) | Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0003-CN-S(P)) | FC, WB | Humanized scFv |
| HPAB-0133CQ-S(P) | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); scFv Fragment | ELISA, FC, Inhib, FuncS | Humanized scFv |
| FAMAB-0288JF-S(P) | Human Anti-GP6 Recombinant Antibody (clone 10B12); scFv Fragment | FC, ELISA, FuncS | Human scFv |
| FAMAB-0289JF-S(P) | Human Anti-GP6 Recombinant Antibody (clone 1C3); scFv Fragment | FC, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0002-CN-F(E)) | FC, WB | Humanized Fab |
| HPAB-0003-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0003-CN-F(E)) | FC, WB | Humanized Fab |
| HPAB-0004-CN-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0004-CN-F(E)) | FC, WB | Mouse Fab |
| HPAB-1711-FY-S(P) | Human Anti-GP6 Recombinant Antibody (clone F1245-4-1); Fab Fragment | ELISA, WB, IHC | Chimeric (mouse/human) Fab |
| HPAB-1712-FY-S(P) | Human Anti-GP6 Recombinant Antibody (clone F1245-5-1); Fab Fragment | ELISA, WB, IHC | Chimeric (mouse/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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