CytoStream™ Rabbit Anti-GYS1 Recombinant Antibody (VS13-YC491)
CAT#: VS13-YC491
The CytoStream™ Rabbit Anti-GYS1 Recombinant Antibody is specific for human and mouse GYS1. GYS1 encodes a glycogen synthase catalyzing glucose addition, associated with muscle storage disease through regulatory pathways affecting glycogen metabolism dynamics. The anti-GYS1 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & microtubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41598/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41598/91527_B_1_6_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle.
High expression in skeletal muscle
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/ihc_selected.jpg
Normal Tissue
Figure 4 Heart muscle
Cardiomyocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_B_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_8_8.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_7_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104812-GYS1
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Specifications
- Immunogen
- Recombinant human glycogen synthase, aa 638-737.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse GYS1
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IHC-P, FC, IP
- Conjugate
- NONE
- Related Disease
- Muscle glycogen storage disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Glycogen Synthase 1; Glycogen Synthase 1 (Muscle); EC 2.4.1.11; GYS; Glycogen [Starch] Synthase, Muscle; GSY;
- Gene ID
- 2997
- UniProt ID
- P13807
- Long Name
- Glycogen Synthase 1
- Sequence Similarities
- Belongs to the glycosyltransferase 3 family.
- Cellular Localization
- Cytosol; Inclusion body; Cell membrane
- Protein Refseq
- NP_001155059.1; NP_002094.2
- Function
- Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1, 4-glucan.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GYS1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0771MZ | Recombinant Mouse Anti-Human GYS1 Antibody (clone 4B8) | ELISA, ICC, IF, WB | Mouse antibody |
| MRO-0680-CN | Rabbit Anti-GYS1 Recombinant Antibody (clone CBACN-248) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-CJ641 | Rabbit Anti-GYS1 (phospho S641) Recombinant Antibody (VS3-CJ641) | WB, ICC, IHC, IP | Rabbit IgG |
| VS3-CJ642 | Rabbit Anti-GYS1 Recombinant Antibody (VS3-CJ642) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS3-FY634 | Recombinant Rabbit Anti-GYS1 (phospho Ser641) Antibody (clone R03-3A1) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1550 | Rabbit Anti-GYS1 Recombinant Antibody (clone DS1550AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY116 | AbPlus™ Anti-GYS1 Magnetic Beads (CBACN-248) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY983 | Anti-GYS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2999 | Anti-Mouse GYS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2998 | Anti-Human GYS1 Immunohistochemistry Kit | IHC |
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