Human Anti-HAVCR1 Recombinant Antibody (Clone 2.70.2) (CAT#: MOB-377YC)
The product is a human monoclonal antibody 2.70.2, also referred to as CR014, against human HAVCR1 (TIM-1). The mAb binds well to recombinant human TIM-1-Fc but not to other human TIM family members, nor to TIM-1 derived from rat or mouse sequences. Epitope mapping using overlapping TIM-1 fragments indicated the epitope to be within the amino acid sequence 209-222 found in the extracellular mucin domain region of the glycoprotein.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7173/if_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7173/if_selected.jpg
Figure 2 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_7_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_7_3.jpg
Figure 3 Rectum
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_4_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_4_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_7_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75697/159393_A_5_6.jpg
Figure 7 RNA cell line category: Group enriched (A549, CACO-2, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113249-HAVCR1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113249-HAVCR1
Specifications
- Immunogen
- Recombinant extracellular domain of human TIM-1 genetically fused with a V5 His-Tag.
- Host Species
- Human
- Type
- Human IgG1 kappa
- Specificity
- Human HAVCR1
- Species Reactivity
- Human
- Clone
- 2.70.2
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4
- Storage
- Store the antibody at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- TIM; KIM1; TIM1; CD365; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1
- Gene ID
- 26762
- UniProt ID
- Q96D42
- Long Name
- Hepatitis A virus cellular receptor 1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0625CL-S(P) | Rat Anti-HAVCR1 Recombinant Antibody; scFv Fragment (TAB-0625CL-S(P)) | ELISA, WB, FC | Rat scFv |
| TAB-0626CL-S(P) | Rat Anti-HAVCR1 Recombinant Antibody; scFv Fragment (TAB-0626CL-S(P)) | ELISA, WB, FC | Rat scFv |
| TAB-0625CL-F(E) | Rat Anti-HAVCR1 Recombinant Antibody; Fab Fragment (TAB-0625CL-F(E)) | ELISA, WB, FC | Rat Fab |
| TAB-0626CL-F(E) | Rat Anti-HAVCR1 Recombinant Antibody; Fab Fragment (TAB-0626CL-F(E)) | ELISA, WB, FC | Rat Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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