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Anti-HAVCR1 Recombinant Antibody Products

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Anti-HAVCR1 Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is a global leader in providing high-quality anti-HAVCR1 recombinant antibody products, meticulously designed to support diverse research and therapeutic development needs worldwide. Our extensive expertise ensures that our global clientele receives cutting-edge solutions for immunology, oncology, and infectious disease studies, accelerating scientific breakthroughs.

HAVCR1: A Pivotal Target for Immunotherapy and Autoimmune Disease

T cell immunoglobulin and mucin domain 1 (TIM-1), also known as HAVCR1, is a crucial transmembrane glycoprotein primarily expressed on activated T cells, B cells, and other immune cells. Recent research highlights its multifaceted roles in immune regulation, viral infections, and tumor immunity, acting as an immune checkpoint. Its involvement in modulating T cell activation, cytokine production, and antigen presentation makes HAVCR1 a significant focus for developing novel immunotherapies and treatments for autoimmune diseases and various cancers.

Alternative Names

HAVCR; HAVCR-1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1; CD365; hepatitis A virus cellular receptor 1; HAVcr-1; T-cell immunoglobulin and mucin domain 1.

Background

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015]

Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Microglial cells, Proximal tubular cells, Excitatory neurons, Oligodendrocytes, Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (A549, CACO-2, RPTEC TERT1)

Interaction

Interacts with STAM (PubMed:29742433). Interacts with SELPLG (PubMed:24703780). (Microbial infection) Interacts with hepatitis A virus capsid proteins. (Microbial infection) Interacts with Ebolavirus envelope glycoprotein GP. (Microbial infection) Interacts with Zika virus envelope protein E.

Molecular function

Host cell receptor for virus entry, Receptor

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Anti-HAVCR1 rAb Products

Our anti-HAVCR1 recombinant antibody products offer unparalleled specificity and affinity, engineered using advanced recombinant technology. These antibodies ensure lot-to-lot consistency and minimal batch variation, providing researchers with reliable tools for critical experiments. Their high purity and robust performance significantly enhance the accuracy and reproducibility of your research, streamlining experimental workflows and yielding dependable results.

Table 1. Featured anti-HAVCR1 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
TAB-664CT Mouse Anti-HAVCR1 Recombinant Antibody (TAB-664CT) Human Mouse IgG FC, IB, Block, Inhib, Funcs, ELISA, FACS, IP, IF
ZG-0707J Rabbit Anti-HAVCR1 Recombinant Antibody (clone 9E1) Human, Mouse Rabbit IgG ELISA, WB
HPAB-1722-FY Human Anti-HAVCR1 Recombinant Antibody (HPAB-1722-FY) Human Human IgG FC, ELISA
HPAB-1721-FY Human Anti-HAVCR1 Recombinant Antibody (HPAB-1721-FY) Human Human IgG FC, ELISA
HPAB-0194CQ Human Anti-HAVCR1 Recombinant Antibody (HPAB-0194CQ) Human Human IgG2, κ ELISA, IHC, FC, FuncS

Creative Quality Control

Creative Biolabs implements a rigorous quality control process for all anti-HAVCR1 recombinant antibody products. Each batch undergoes comprehensive validation to confirm specificity, sensitivity, and functionality. This meticulous approach guarantees that our antibodies meet the highest industry standards, ensuring superior performance and reliability for your most demanding applications.

Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-HAVCR1 antibody
(Cat# TAB-664CT, Creative Biolabs).

Fig.2 SEC-HPLC analysis. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-HAVCR1 antibody
(Cat# TAB-664CT, Creative Biolabs).

Fig.3 ELISA analysis. (Creative Biolabs Original)Fig.3 ELISA analysis of anti-HAVCR1 antibody
(Cat# TAB-664CT, Creative Biolabs).

Fig.4 WB analysis. (Creative Biolabs Original)Fig.4 WB analysis of anti-HAVCR1 antibody
(Cat# TAB-664CT, Creative Biolabs).

Fig.5 DB analysis. (Creative Biolabs Original)Fig.5 DB analysis of anti-HAVCR1 antibody
(Cat# TAB-664CT, Creative Biolabs).

Fig.6 WB analysis. (Creative Biolabs Original)Fig.6 WB analysis of anti-HAVCR1 antibody
(Cat# ZG-0707J, Creative Biolabs).

Customer Reviews

Excellent
So***r
Human Anti-HAVCR1 Recombinant Antibody (HPAB-1721-FY) (HPAB-1721-FY)
The anti-HAVCR1 antibody from Creative Biolabs has transformed our immunology research. Its remarkable specificity enabled us to obtain clear, interpretable findings in our flow cytometry investigations, considerably contributing to our understanding of T cell regulation.
15/Mar/2023
Excellent
An***i
Rabbit Anti-HAVCR1 Recombinant Antibody (clone 9E1) (ZG-0707J)
Using Creative Biolabs' anti-HAVCR1 recombinant antibody was a seamless experience. The product's consistent performance across multiple assays saved us considerable time and resources, eliminating the need for extensive optimization. It truly delivered on its promise of high quality and reliability, making our experiments much more efficient.
11/Jun/2023
Excellent
Ji***n
Human Anti-HAVCR1 Recombinant Antibody (HPAB-0194CQ) (HPAB-0194CQ)
We applied Creative Biolabs' anti-HAVCR1 antibody in our cancer immunotherapy studies, and the results were outstanding. Its robust binding capabilities and excellent signal-to-noise ratio were crucial for our in vivo models, providing compelling data that supports our therapeutic development efforts.
13/Aug/2024

rAb Production

The production of our anti-HAVCR1 recombinant antibody products leverages state-of-the-art mammalian expression systems, ensuring optimal post-translational modifications and biological activity. Our streamlined, scalable manufacturing process adheres to strict guidelines, guaranteeing high yields and consistent product quality. This advanced production pipeline enables us to provide superior antibodies for both research and potential clinical applications.

Featured Anti-HAVCR1 Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-HAVCR1 recombinant antibody production.

Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-HAVCR1 recombinant antibody production.

rAb Modalities

Creative Biolabs’ anti-HAVCR1 recombinant antibodies are available in multiple modalities, including antibody fragments, bispecific antibodies, and many other formats, offering versatility for various experimental setups.

Fig.9 HAVCR1 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-HAVCR1 recombinant antibody production and modalities.

HAVCR1-Targeted Drug Information

Table 2. Public drug targeting HAVCR1.

Company Research phase Classification Condition
Genentech (Originator) Phase II Humanized Monoclonal Antibodies Asthma
Asthma, allergic
Rhinitis, allergic
Urticaria
Amgen
Celldex (Celldex Therapeutics)
Celldex Therapeutics (Originator)
Phase I Antibodies
Antibody-Drug Conjugates (ADCs)
Auristatins
Cancer Immunotherapy
Prodrugs
Cancer
Cancer, kidney (renal cell carcinoma)
Cancer, ovary (clear cell carcinoma)
Huazhong University of Science and Tech (Originator) Biological Testing Polypeptides, from 10 AA to 40 AA Acute kidney injury
Military Medical Institute (Originator) Biological Testing Human Monoclonal Antibodies Ebola virus disease
Marburg virus hemorrhagic fever
People Hospital Guangxi Zhuang Auton Reg (Originator) Biological Testing Fc Fusion Proteins
Polypeptides, from 41 AA
Allergy
Celdara Medical (Originator) Biological Testing Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Cancer, ovary
Biogen (Originator)
University of Iowa (Originator)
Biological Testing Chimeric Monoclonal Antibodies Asthma, allergic
Amgen (Originator) Biological Testing Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is committed to enhancing your study with excellent anti-HAVCR1 recombinant antibody products. Our dedication to scientific excellence and client satisfaction motivates us to provide creative solutions. Please contact us if you are interested in our products or want to discuss your unique project needs. Our skilled staff is here to help you achieve your research goals.

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