Human Anti-HCV E2 Vaccinal Antibody (VS-0625-XY18)
CAT#: VS-0625-XY18
This vaccinal antibody targets HCV E2 and is applicable for ELISA, IF, and neutralization assays. With Fc segment engineering, it induces vaccine-like effects and enhances antiviral efficacy by improving antibody-dependent cellular cytotoxicity and prolonging half-life, enabling robust detection and functional inhibition of HCV.
Specifications
- Target
- HCV E2
- Host Animal
- Human
- Applications
- ELISA; IF; Neut
- Specificity
- HCV E2
- Species Reactivity
- HCV
- Type
- Human IgG
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Protein A purified
- Epitope
- It binds to the conserved epitope in the E2 front layer
- Format
- Liquid
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- E2 is the main HCV receptor binding protein and the primary target for broadly neutralizing antibodies (bnAbs). The receptor binding domain (residues 384 to 645), also known as E2 core domain, is modified by up to 11 N-linked glycans and contains several variable regions that increase the genetic diversity of HCV for evasion of the immune system. Crystal structures of E2 from different HCV strains are all very similar, with the E2 core domain consisting of a central immunoglobulin (Ig)β-sandwich fold stabilized by eight disulfides and flanked by N-terminal hypervariable region 1, a front layer, and a C-terminal back layer (residues 597 to 645). The high density of the disulfide bonds contributes to the high thermal stability of E2, although the receptor binding site in recombinant E2 exhibits high conformational flexibility.
- Related Disease
- Liver failure, Hepatocellular carcinoma
- Alternative Names
- Hepatitis C virus envelope glycoprotein E2
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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