Rabbit Anti-HDAC6 Recombinant Antibody (VS13-YC503)
CAT#: VS13-YC503
The Rabbit Anti-HDAC6 Recombinant Antibody is specific for human HDAC6. HDAC6 has two independent catalytic domains, providing histone deacetylase activity and repressing transcription. It contributes to the alteration of chromosome structures affecting transcription factor access to DNA. The anti-HDAC6 antibody can be used for Western blot (1/1000-1/5000), Immunocytochemistry (1/50-1/200), Immunofluorescence (1/50-1/200), Immunohistochemistry-paraffin (1/50-1/400).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26321/if_selected.jpg
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Specifications
- Immunogen
- Recombinant human HDAC6, aa 1-50.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HDAC6
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC-P, IP
- Conjugate
- NONE
- Related Disease
- Alexander Disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/5000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/400
Target
- Alternative Names
- Histone Deacetylase 6; Protein Phosphatase 1, Regulatory Subunit 90; EC 3.5.1.98; HD6; KIAA0901; PPP1R90; CPBHM; JM21;
- Gene ID
- 10013
- UniProt ID
- Q9UBN7
- Long Name
- Histone Deacetylase 6
- Cellular Localization
- Cytoplasm; Cytoskeleton; Nucleus; Perikaryon
- Protein Refseq
- XP_047297659.1; XP_047297660.1
- Function
- Required for cilia disassembly; via deacetylation of alpha-tubulin (PubMed:17604723, 26246421).
Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141).
Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532).
Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression.
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Related Diseases
Alcoholism
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HDAC6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1577 | Rabbit Anti-HDAC6 Recombinant Antibody (clone DS1577AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0097C | Mouse Anti-HDAC6 Recombinant Antibody (clone ABT-HDAC6) | IHC-P, IF | Mouse IgG |
| ZG-0712J | Rabbit Anti-HDAC6 Recombinant Antibody (clone 2H12) | ELISA, WB, IHC, IP | Rabbit IgG |
| VS3-WK1186 | Mouse Anti-HDAC6 Recombinant Antibody (VS3-WK1186) | IHC | Mouse IgG1 |
| VS3-FY663 | Recombinant Mouse Anti-HDAC6 Antibody (clone 10G7-4D10-6A7) | IHC-P | Mouse IgG1 |
| VS7-0425-WR28 | Mouse Anti-HDAC6 Recombinant Antibody (clone 4G6F9) | FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY241 | Mouse Anti-NHP HDAC6 Recombinant Antibody (clone OTI4C5) | WB, IHC, IF, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1004 | Anti-HDAC6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3101 | Anti-Human HDAC6 Immunohistochemistry Kit | IHC |
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