Recombinant Anti-HGF Eliminating Antibody, pH-Sensitive (VS-0625-YC141)
CAT#: VS-0625-YC141
The anti-HGF eliminating antibody is an engineered pH-sensitive antibody against human HGF. HGF stimulates cell growth across various tissues, acting without protease activity. The antibody has a novel HGF-sweeping activity in vivo, which selectively eliminatesthe soluble HGF from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000019991-HGF
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Specifications
- Host Species
- Human
- Type
- Human IgG2 kappa
- Specificity
- Human HGF
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-080 | Human Anti-HGF Recombinant Antibody (TAB-080) | WB, ELISA, FC, IP, FuncS, IF, Neut | Human IgG2, κ |
| TAB-076CT | Anti-Human HGF/SF Recombinant Antibody (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-S(P) | Anti-Human HGF/SF Recombinant Antibody scFv Fragment (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-F(E) | Anti-Human HGF/SF Recombinant Antibody Fab Fragment (2C3) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-749 | Anti-HGF Recombinant Antibody (TAB-749) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-075CT | Human Anti-HGF Recombinant Antibody (TAB-075CT) | ELISA, Neut | Humanized antibody |
| TAB-075CT-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (TAB-075CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-075CT-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (TAB-075CT-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-132 | Rabbit Anti-HGF Recombinant Antibody; Fab Fragment (PFBL-132) | WB, ELISA, FuncS | Rabbit Fab |
| HPAB-0713-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone AB012); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0821-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S265109B10); Fab Fragment | Neut, ELISA | Mouse Fab |
| HPAB-0822-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S260115C11); Fab Fragment | Neut, ELISA | Mouse Fab |
| HPAB-0823-FY-S(P) | Human Anti-HGF Recombinant Antibody (clone S260105B02); Fab Fragment | Neut, ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078CT | Llama Anti-HGF Recombinant Single Domain Antibody (TAB-078CT) | Block | Llama VHH |
| HPAB-0993WJ | Recombinant Camelid Anti-HGF Single Domain Antibody (HPAB-0993WJ) | ELISA | Camelid VHH |
| HPAB-0994WJ | Recombinant Human Anti-HGF Antibody (HPAB-0994WJ) | ELISA | Humanized sdAb |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-900CQ | Mouse Anti-HGF Recombinant Antibody (clone 24612.111) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-901CQ | Mouse Anti-HGF Recombinant Antibody (clone 5D20) | WB, Neut | Mouse IgG1 |
| NEUT-902CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL070) | Neut, WB | Mouse IgG1 |
| NEUT-903CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL435) | WB, Neut | Mouse IgG1 |
| NEUT-904CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL1017) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1591 | Rabbit Anti-HGF Recombinant Antibody (clone DS1591AB) | ELISA | Rabbit IgG |
| MOR-4217 | Rabbit Anti-HGF Recombinant Antibody (clone SI296DS) | ELISA | Rabbit IgG |
| MOR-4585 | Rabbit Anti-HGF Recombinant Antibody (clone TH98DS) | WB, IF, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0651-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0651-CN) | IHC, WB, FC | Mouse IgG1, κ |
| HPAB-0652-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0652-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0653-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0653-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0654-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0654-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0655-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0655-CN) | ELISA, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-130 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-130) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-749 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-749) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-080 | Afuco™ Anti-HGF Recombinant Antibody (AFC-TAB-080), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0713-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone AB012); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0821-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S265109B10); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0822-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S260115C11); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0823-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S260105B02); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0990WJ-S(P) | Human Anti-HGF Recombinant Antibody (clone 2.12.1); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1015 | Anti-HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3130 | Anti-Mouse HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3129 | Anti-Human HGF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY25 | Human Anti-HGF (clone BPC2015) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
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