Human Anti-HGF (clone BPC2015) scFv-Fc Chimera
CAT#: VS-0425-FY25
The anti-HGF scFv-Fc antibody exhibits a strong binding affinity for human hepatocyte growth factor (HGF). This engineered antibody combines a single-chain variable fragment (scFv) with an Fc region derived from an immunoglobulin. The scFv component is responsible for recognizing and specifically binding to HGF, while the Fc portion enhances the stability and overall therapeutic potential of the antibody.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000019991-HGF
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HGF
- Species Reactivity
- Human
- Clone
- BPC2015
- Applications
- ELISA, Inhibition
- Related Disease
- Angiogenesis-mediated disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The average IC₅₀ value of BPC-2025 is 0.4 nM.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Hepatocyte Growth Factor; Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor); Fibroblast-Derived Tumor Cytotoxic Factor; Lung Fibroblast-Derived Mitogen; Hepatopoietin-A; Scatter Factor; HPTA; SF
- Gene ID
- 3082
- UniProt ID
- P14210
- Long Name
- Hepatocyte Growth Factor
- Sequence Similarities
- Belongs to the peptidase S1 family. Plasminogen subfamily.
- Post Translation Modifications
- The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.
Glycosylation at Asn294, Asn402, Thr476, Asn566, and Asn653
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 5 sites, 14 N-linked glycans (4 sites), 2 O-linked glycans (1 site)
- Protein Refseq
- XP_047276249.1; NP_000592.3; NP_001010931.1; NP_001010932.1; NP_001010933.1
- Function
- Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Activates MAPK signaling following TMPRSS13 cleavage and activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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|---|---|---|---|
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| TAB-076CT | Anti-Human HGF/SF Recombinant Antibody (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-S(P) | Anti-Human HGF/SF Recombinant Antibody scFv Fragment (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-F(E) | Anti-Human HGF/SF Recombinant Antibody Fab Fragment (2C3) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-749 | Anti-HGF Recombinant Antibody (TAB-749) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-075CT | Human Anti-HGF Recombinant Antibody (TAB-075CT) | ELISA, Neut | Humanized antibody |
| TAB-075CT-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (TAB-075CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-075CT-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (TAB-075CT-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-132 | Rabbit Anti-HGF Recombinant Antibody; Fab Fragment (PFBL-132) | WB, ELISA, FuncS | Rabbit Fab |
| HPAB-J0117-YC-F(E) | Human Anti-HGF Recombinant Antibody Fab Fragment (HPAB-J0117-YC-F(E)) | ELISA, Neut, FuncS | Chimeric (mouse/human) Fab |
| HPAB-1856-FY-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-1856-FY-S(P)) | ELISA | Human scFv |
| HPAB-1857-FY-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-1857-FY-S(P)) | ELISA | Human scFv |
| HPAB-1858-FY-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-1858-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078CT | Llama Anti-HGF Recombinant Single Domain Antibody (TAB-078CT) | Block | Llama VHH |
| HPAB-0993WJ | Recombinant Camelid Anti-HGF Single Domain Antibody (HPAB-0993WJ) | ELISA | Camelid VHH |
| HPAB-0994WJ | Recombinant Human Anti-HGF Antibody (HPAB-0994WJ) | ELISA | Humanized sdAb |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-900CQ | Mouse Anti-HGF Recombinant Antibody (clone 24612.111) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-901CQ | Mouse Anti-HGF Recombinant Antibody (clone 5D20) | WB, Neut | Mouse IgG1 |
| NEUT-902CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL070) | Neut, WB | Mouse IgG1 |
| NEUT-903CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL435) | WB, Neut | Mouse IgG1 |
| NEUT-904CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL1017) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1591 | Rabbit Anti-HGF Recombinant Antibody (clone DS1591AB) | ELISA | Rabbit IgG |
| MOR-4217 | Rabbit Anti-HGF Recombinant Antibody (clone SI296DS) | ELISA | Rabbit IgG |
| MOR-4585 | Rabbit Anti-HGF Recombinant Antibody (clone TH98DS) | WB, IF, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0651-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0651-CN) | IHC, WB, FC | Mouse IgG1, κ |
| HPAB-0652-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0652-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0653-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0653-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0654-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0654-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0655-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0655-CN) | ELISA, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-130 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-130) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-749 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-749) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-080 | Afuco™ Anti-HGF Recombinant Antibody (AFC-TAB-080), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0990WJ-S(P) | Human Anti-HGF Recombinant Antibody (clone 2.12.1); scFv Fragment | ELISA | Human scFv |
| HPAB-0991WJ-S(P) | Human Anti-HGF Recombinant Antibody (clone LRMR2B8); scFv Fragment | ELISA | Human scFv |
| HPAB-0994WJ-S(P) | Human Anti-HGF Recombinant Antibody (clone HGF13hum5); scFv Fragment | ELISA | Humanized scFv |
| HPAB-1856-FY-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (HPAB-1856-FY-F(E)) | ELISA | Human Fab |
| HPAB-1857-FY-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (HPAB-1857-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1015 | Anti-HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3130 | Anti-Mouse HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3129 | Anti-Human HGF Immunohistochemistry Kit | IHC |
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