Recombinant mouse antibody to gp160(592-608). T32 binds to region 597-613: WGCSGKLICTTAVPWNA.
Figure 1 E2-derived peptides bind to the disulfide loop of gp41.
Competitive binding of E2 peptides and different gp41 targeting mAbs to immobilized recombinant gp41MN.
Eissmann, K., Mueller, S., Sticht, H., Jung, S., Zou, P., Jiang, S., ... & Reil, H. (2013). HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop. PloS one, 8(1), e54452.
Figure 2 293T cells expressing CD4, CCR5, or CXCR4 were preincubated with E2-derived peptides, E2340-Fc and Fc protein as well as specific controls that bind to gp120.
No influence of E2 peptides or intact E2 protein on the binding efficiency between
gp120 and CD4, CCR5, or CXCR4 respectively, was observed after normalization of band intensity with the gel loading control Hsp90.
Eissmann, K., Mueller, S., Sticht, H., Jung, S., Zou, P., Jiang, S., ... & Reil, H. (2013). HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop. PloS one, 8(1), e54452.
Figure 3 293T cells expressing NL4-3 envelope (X4env) or empty plasmid as control were incubated with sCD4 and FITC-conjugated E2 peptides, respectively.
Peptide binding was analyzed by flow cytometry.
Eissmann, K., Mueller, S., Sticht, H., Jung, S., Zou, P., Jiang, S., ... & Reil, H. (2013). HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop. PloS one, 8(1), e54452.
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• Confirmed specificity
• High repeatability
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody; scFv Fragment (PSBL-177) | WB, ELISA, Neut, FuncS | Human scFv |
PSBL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 3H+109L); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
PFBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); Fab Fragment | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
MRO-3735CQ | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1B8.env (1B8)) | WB, IF | Human IgG2, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
MRO-3768CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66.6 Y100cHCS); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3769CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1131-A); Fab Fragment | ELISA, WB | Human Fab |
MRO-3771CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1A1); Fab Fragment | ELISA, WB | Human Fab |
MRO-3772CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4D4); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
MRO-088LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (2D7) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
MRO-091LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1) | ELISA | Human antibody |
MRO-100LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (N7019b) | ELISA | Human antibody |
MRO-101LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (K24-3b) | ELISA | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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