Does this scFv bind to multiple HIV-1 clades?

Yes, the clone HGN35 binds to Env from clades A, B, and D, and to gp41 from clade B. It cross-competes with MAb 3D6 for binding to gp120, although it does not neutralize the virus.

What is the format and application of this antibody?

This is a recombinant human antibody scFv fragment. It recognizes HIV-1 gp160 (residues 599-604) and has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA).

Human Anti-HIV-1 gp160 Recombinant Antibody (clone HGN35); scFv Fragment

CAT#: MRO-3674CQ-S(P)

Recombinant human antibody scFv fragment to gp160(599-604). HGN35 can bind to Env from clades A, B and D, and to gp41 from clade B. It cross-competed with MAb 3D6 for binding to gp120. HGN35 did not neutralize any HIV-1 isolates.

Specifications

Host Species
Human

Type
Human scFv

Specificity
Recognizes HIV-1 gp160(599-604)

Species Reactivity
HIV-1

Clone
HGN35

Applications
ELISA

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope

Gene ID
155971

UniProt ID
P04578

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Recognizes Multiple Clades

The scFv fragment HGN35 is a valuable tool. It successfully binds to Env from clades A, B, and D in our ELISA setups. Its cross-clade binding ability makes it useful for studying epitope conservation in HIV-1 gp160.

Specific gp160 Binder

We used this recombinant human antibody scFv fragment to detect gp160. It specifically recognizes the region 599-604. The purity is high, and it works reliably for our structural studies of the viral envelope without neutralizing interference.

Q&As

Does this scFv bind to multiple HIV-1 clades?

A: Yes, the clone HGN35 binds to Env from clades A, B, and D, and to gp41 from clade B. It cross-competes with MAb 3D6 for binding to gp120, although it does not neutralize the virus.
What is the format and application of this antibody?

A: This is a recombinant human antibody scFv fragment. It recognizes HIV-1 gp160 (residues 599-604) and has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA).

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - MRO-3674CQ-S(P).pdf

MSDS

MSDS - MRO-3674CQ-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

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CAT
Product Name

See other products for "HIV-1 gp160"

Select a product category from the dropdown menu below to view related products.

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PABL-177	Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-177)	WB, ELISA, Neut, FuncS	Human IgG

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PABL-178	Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-178)	WB, ELISA, FuncS	Human IgG

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PABL-179	Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128)	WB, ELISA, FuncS	Human IgG

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PABL-180	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C)	WB, ELISA, Neut, FuncS	Human IgG, κ

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PABL-181	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01)	FC, Neut, FuncS	Human IgG

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PSBL-177	Human Anti-HIV-1 gp160 Recombinant Antibody; scFv Fragment (PSBL-177)	WB, ELISA, Neut, FuncS	Human scFv

CAT	Product Name	Application	Type
PSBL-178	Human Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (PSBL-178)	WB, ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
PSBL-179	Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128); scFv Fragment	WB, ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
PSBL-180	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C); scFv Fragment	WB, ELISA, Neut, FuncS	Human scFv

CAT	Product Name	Application	Type
PSBL-181	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01); scFv Fragment	FC, Neut, FuncS	Human scFv

CAT	Product Name	Application	Type
PFBL-177	Human Anti-HIV-1 gp160 Recombinant Antibody; Fab Fragment (PFBL-177)	WB, ELISA, Neut, FuncS	Human Fab

CAT	Product Name	Application	Type
PFBL-178	Human Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (PFBL-178)	WB, ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
PFBL-179	Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128); Fab Fragment	WB, ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
PFBL-180	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C); Fab Fragment	WB, ELISA, Neut, FuncS	Human Fab

CAT	Product Name	Application	Type
PFBL-181	Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01); Fab Fragment	FC, Neut, FuncS	Human Fab

CAT	Product Name	Application	Type
MRO-091LC	Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1)	ELISA	Human antibody

CAT	Product Name	Application	Type
MRO-091LC-S(P)	Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (MAb CL1)	ELISA	Human antibody

CAT	Product Name	Application	Type
MRO-091LC-F(E)	Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1)	ELISA	Human antibody

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