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    Monkey Anti-HLA-DRA Recombinant Antibody (clone MS-GPC-8-10-57) (CAT#: VS-0724-XY78)

    This product is a recombinant monkey antibody binding to HLA-DRA (Major histocompatibility complex, class II, DR alpha). The antibody seems to recognise a f1 domain epitope that is highly conserved among allelic HLA-DRA molecules and it has high affinity against HLA-DRA. It has been tested using ELISA, Bio-layer interferometry and Neutralizaiton assay.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
    Figure 3 High expression in lymph node
    Figure 3 High expression in lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
    Figure 4 Tonsil
    Figure 4 Tonsil
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
    RNA Expression
    Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
    Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA

    Specifications

    • Host Species
    • Monkey
    • Type
    • Monkey IgG4
    • Specificity
    • HLA-DRA
    • Species Reactivity
    • Human
    • Clone
    • MS-GPC-8-10-57
    • Applications
    • ELISA, BLI, Neut
    • Related Disease
    • Graham Little-Piccardi-Lassueur Syndrome; Autoimmune Hepatitis

    Product Property

    • Purification
    • Protein A affinity purified
    • Purity
    • >95%, determined by SDS-PAGE
    • Format
    • Liquid
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

    Applications

    • Application Notes
    • BLI: The KD value of MS-GPC-8-10-57 agaisnt HLA-DRA is 2.7 ± 0.3 nM.

    Target

    • Alternative Names
    • HLA-DRA1
    • Cellular Localization
    • Cell membrane; Endoplasmic reticulum membrane
    • Post Translation Modifications
    • Glycosylation at Asn103 and Asn143.
      Ubiquitination at Lys244.
    • Function
    • An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
      In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells.

    Recommended Products

    Isotype Control

    Recommended Dilution Buffer

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "HLA-DRA"

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    MOB-0310MZ Recombinant Mouse Anti-Human HLA-DR antigen, Alpha-Chain Antibody (clone UAL.2B6) IHC Mouse antibody
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