Recombinant Human Anti-IAV HA Antibody (3E1)
CAT#: PABC-312
This product is a recombinant Human antibody that can recognize IAV HA. 3E1 exhibited broad neutralizing activity against H1 and H5 subtype viruses in vitro and protected mice against H1N1 and H5N6 viruses in vivo by inhibiting the low pH-induced HA conformational rearrangement, hence blocking membrane fusion.
Published Data
BLI
Figure 1 In vitro binding of 3E1 mAb.
Binding affinity (Kd) of 3E1 mAb to the HAs of various strains of H1, H5 and H3 subtype IAVs. Data represent a representative experiment from three independent experiments.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
Neut
Figure 2 In vitro neutralization activity of 3E1 mAb.
In vitro microneutralization (IC₅₀) of 3E1 mAb against various strains of H1, H5 and H3 subtype IAVs. Graphs used for IC₅₀ values determined by averaging neutralization titre of three independent experiments.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
FuncS
Figure 3 Prophylactic and therapeutic efficacy of 3E1 mAb in mice.
Prophylactic efficacy of 3E1 mAb against a lethal challenge with the A/Sichuan/09/2009(H1N1) virus.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- IAV HA
- Species Reactivity
- H1N1 and H5N6
- Clone
- 3E1
- Applications
- ELISA, BLI, Neut
- Related Disease
- Infectious disease
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody 3E1 has been reported in applications of Enzyme-linked Immunosorbent Assay, Biolayer interferometry, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- IAV HA; Influenza A Virus Hemagglutinin; Hemagglutinin HA
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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