Rabbit Anti-IFNGR1 Recombinant Antibody (clone R08-9H9)
CAT#: VS3-FY1745
Clone R08-9H9 is a rabbit recombinant monoclonal antibody that detects human IFNGR1, a 54 kDa member of the immunodlobulin superfamily. It cross-reacts with mouse, rat. This antbody has been tested by western blot analysis of IFNGR1 in K562, C6, 3T3, Hela lysates.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29213/273_A10_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong membranous positivity in cells in red pulp.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_B_9_4_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous and cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25889/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_B_8_5.jpg
Normal Tissue
Figure 5 Lung
Macrophages Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63871/148756_A_1_4.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000027697-IFNGR1
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WB
Figure 1 Anti-IFNGR1 Antibody (VS3-FY1745) in WB.
The IFNGR1 expression in K562, C6, 3T3, Hela lysates were detected using the anti-Interferon gamma Receptor 1 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human IFNGR1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat IFNGR1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-9H9
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 54 kDa, while the observed molecular weight stands at 100 kDa.
- Related Disease
- Mycobacterial disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Interferon Gamma Receptor 1
- Gene ID
- 3459
- UniProt ID
- P15260
- Sequence Similarities
- Belongs to the type II cytokine receptor family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-457 is required for IFNG receptor signal transduction (PubMed:8156998).
Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner (PubMed:29343571).4 Publications
Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation (PubMed:29343571).
Proteasomally degraded through 'Lys-48'-mediated ubiquitination (PubMed:28883123).
Ubiquitination is necessary for efficient IFNGR1 signaling (PubMed:28883123).
- Protein Refseq
- XP_006715533.1; XP_011534095.1; XP_011534096.1; XP_047274682.1; XP_054211301.1
- Function
- Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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