AibGenesis™ Rabbit Anti-IQGAP1 Recombinant Antibody (AibG-Rb-IQ517)
CAT#: VS-0426-FY517
Discovered via our AI-powered antibody discovery platform, this Rabbit IgG targets IQGAP1. Validated for WB, IHC, and FC in Human samples, it serves as a robust scaffold marker for researchers investigating the regulation of the cytoskeleton, cell-cell adhesion, and growth factor signaling pathways.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/671_E1_1_selected.jpg
Normal Tissue
Figure 2 Endometrium 1
High expression in endometrium 1
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14055/33083_B_6_3_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_5_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_9_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_9_4.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000140575-IQGAP1
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IQGAP1
- Species Reactivity
- Human
- Clone
- AibG-Rb-IQ517
- Applications
- Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Flow Cytometry
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Thyroid Carcinoma
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 150 mM NaCl, 50% Glycerol
- Preservative
- 0.02% New type preservative N
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:2000), Immunohistochemistry (1:100-1:500), Immunocytochemistry/Immunofluorescence (1:100-1:200), Flow Cytometry (1:20-1:50)
Target
- Alternative Names
- Iqgap1; p195; SAR1
- Gene ID
- 8826
- UniProt ID
- P46940
- Long Name
- IQ Motif Containing GTPase Activating Protein 1
- Cellular Localization
- Cell membrane, Nucleus, Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys88, Lys348, Lys811, Lys1088, Lys1144, Lys1155, Lys1165, Lys1230, Lys1477, and Lys1528 (NX_P46940 [NX_P46940-1])
Modification sites at PhosphoSitePlus (P46940)
Glycosylation from GlyGen (P46940) 2 sites, 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_047289160.1
- Function
- Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton.
Binds to activated CDC42 but does not stimulate its GTPase activity.
It associates with calmodulin.
Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IQGAP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0988CT | Recombinant Mouse anti-Human IQGAP1 Monoclonal antibody (EML945) | ICC, IF, IHC-P, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1849 | Hi-Affi™ Recombinant Rabbit Anti-IQGAP1 Monoclonal Antibody (DS1849AB) | ICC, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0864-CN | Recombinant Rabbit Anti-IQGAP1 Monoclonal Antibody (JG38-74) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK489 | Rabbit Anti-IQGAP1 Recombinant Antibody (clone JG38-74) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY3395 | Rabbit Anti-IQGAP1 Recombinant Antibody (clone R01-9S9) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY283 | Mouse Anti-NHP IQGAP1 Recombinant Antibody (clone AF1) | WB, IF | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1135 | Anti-IQGAP1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3578 | Anti-Mouse IQGAP1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3577 | Anti-Human IQGAP1 Immunohistochemistry Kit | IHC |
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