Human Anti-ITGB3 Recombinant Soluble TCR (clone D48T12) (CAT#: scTCR-0575YC-S(P))
Recombinant Human single-chain TCR (scTCR) D48T12 recognizes truncated integrin beta 3 (AWCSDEALPPGS) in the context of HLA-DRB3*01:01. The scTCR is responsible for the specificity of T cells.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
Figure 4 RNA cell line category: Cell line enhanced (EFO-21, HEL, RPTEC TERT1, U-87 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
Specifications
- Host Species
- Human
- Target
- ITGB3
- Species Reactivity
- Human
- Epitope
- AWCSDEALPPGS
- MHC
- HLA-DRB3*01:01
- Clone
- D48T12
- Type
- Single-Chain TCR
- Related Disease
- Fetal and neonatal alloimmune thrombocytopenia (FNAIT)
Target
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-785-sdAb | Recombinant Anti-human ITGB3 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
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