Rabbit Anti-KITLG Recombinant Antibody (VS3-CJ779)
CAT#: VS3-CJ779
This product is a rabbit antibody that recognizes human KITLG.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/1515_E4_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows nuclear positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_5_4_selected.jpg
Normal Tissue
Figure 3 Spleen
Cells in red pulp
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70395/159850_B_7_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000049130-KITLG
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human KITLG
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- SF; MGF; SCF; SLF; DCUA; FPH2; FPHH; KL-1; Kitl; WS2F; SHEP7; DFNA69
- Gene ID
- 4254
- UniProt ID
- P21583
- Sequence Similarities
- Belongs to the SCF family.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Secreted
- Post Translation Modifications
- A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.
Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.
A soluble form exists as a cleavage product of the extracellular domain.
- Protein Refseq
- NP_000890.1; NP_003985.2
- Function
- Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "KITLG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-601-F(E) | Recombinant Anti-human KITLG Antibody Fab Fragment | FC, ELISA, FuncS | Fab |
| MHH-601-F(E) | Recombinant Human Anti-human KITLG Antibody Fab Fragment | FC, ELISA, FuncS | Fab |
| HPAB-0299CQ-F(E) | Human Anti-KITLG Recombinant Antibody (clone A2-G8); Fab Fragment | ELISA, FC, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-601-S(P) | Recombinant Anti-human KITLG Antibody scFv Fragment | FC, Neut, Biosensors, FuncS | scFv |
| MHH-601-S(P) | Recombinant Human Anti-human KITLG Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0299CQ-S(P) | Human Anti-KITLG Recombinant Antibody (clone A2-G8); scFv Fragment | ELISA, FC, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-601 | Recombinant Human Anti-human KITLG Antibody | ELISA, WB, IF, FuncS | IgG |
| MOB-1398CT | Recombinant Mouse anti-Human KITLG Monoclonal antibody (2.3_3I6-2D20) | ELISA | |
| HPAB-0299CQ | Human Anti-KITLG Recombinant Antibody (clone A2-G8) | ELISA, FC, Neut | Human IgG |
| MRO-1369-CN | Recombinant Rabbit Anti-KITLG Monoclonal Antibody (CBACN-497) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK1968 | Recombinant Rat Anti-KITLG Capture Antibody (clone 17E8) | ELISA | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0475CL | Mouse Anti-KITLG Recombinant Antibody (TAB-0475CL) | ELISA, Block, FuncS | Mouse IgG |
| TAB-0475CL-S(P) | Mouse Anti-KITLG Recombinant Antibody; scFv Fragment (TAB-0475CL-S(P)) | ELISA, Block, FuncS | Mouse scFv |
| TAB-0475CL-F(E) | Mouse Anti-KITLG Recombinant Antibody; Fab Fragment (TAB-0475CL-F(E)) | ELISA, Block, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1949 | Hi-Affi™ Recombinant Rabbit Anti-KITLG Monoclonal Antibody (DS1949AB) | FC, ICC, IF, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC583 | Recombinant Anti-KITLG Vesicular Antibody, EV Displayed (VS-0425-YC583) | ELISA, FC, Neut, Cell-uptake |
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