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  • Mouse Anti-KRT18 (C-Terminus) Recombinant Antibody (VS3-CJ423)

Mouse Anti-KRT18 (C-Terminus) Recombinant Antibody (VS3-CJ423) (CAT#: VS3-CJ423)

This product is a mouse antibody that recognizes human KRT18 (C-Terminus).

See more Formats products for KRT18
Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1605/if_selected.jpg
Figure 2 IHC staining of human placenta
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows distinct membranous and cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1605/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1605/21_G9_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1605/22_G9_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Figure 5 Colon
(Endocrine cells
Staining:

High

Intensity: Strong

Enterocytes
Staining:

High

Intensity: Strong
Quantity:>75%

Goblet cells
Staining:

High

Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30/252_A_8_3.jpg
Figure 6 Liver
Figure 6 Liver
(Cholangiocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30/252_A_9_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Collecting ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Distal tubules
Staining:

High

Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30/252_A_7_5.jpg
Figure 8 Placenta
Figure 8 Placenta
(Cytotrophoblasts
Staining:

High

Intensity: Strong
Quantity:>75%
Endothelial cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Hofbauer cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:

High

Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:

High

Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30/252_A_3_7.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3)
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111057-KRT18
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3)
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111057-KRT18

Specifications

  • Immunogen
  • KLH-conjugated synthetic peptide selected from the 400-430 region of human CYK18
  • Host Species
  • Mouse
  • Type
  • Mouse IgG3
  • Specificity
  • Human KRT18 (C-Terminus)
  • Species Reactivity
  • Human
  • Applications
  • WB, IF
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein A/G affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • PBS, pH 7.3.
  • Preservative
  • 0.09% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot (1:2000), Immunofluorescence (1:25).

Target

  • Alternative Names
  • K18; CK-18; CYK18
  • Sequence Similarities
  • Belongs to the intermediate filament family.
  • Cellular Localization
  • Cytoplasm, Intermediate filament, Keratin, Nucleus
  • Post Translation Modifications
  • Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
    Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
    O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
  • Function
  • Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Recommended Products

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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CAT Product Name Application Type
MOB-2242MZ Recombinant Mouse Anti-Human KRT18 Antibody ICC/IF, IHC-P, WB Mouse antibody
ZG-0241J Mouse Anti-KRT18 Recombinant Antibody (ZG-0241J) IHC-P, IF/ICC Mouse IgG
ZG-0242J Mouse Anti-KRT18 Recombinant Antibody (ZG-0242J) IHC-P, IF Mouse IgG
ZG-0243J Mouse Anti-KRT18 Recombinant Antibody (clone 1B3) WB, IF/ICC Mouse IgG
ZG-0244J Mouse Anti-KRT18 Recombinant Antibody (clone 2F7) WB Mouse IgG

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