Mouse Anti-LAMP1 Recombinant Antibody (VS3-CJ587) (CAT#: VS3-CJ587)
This product is a mouse antibody that recognizes human LAMP1.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Ihc staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong granular positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14750/34136_A_5_5_selected.jpg
(Immunohistochemical staining of human urinary bladder shows strong granular positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14750/34136_A_5_5_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/ihc_selected.jpg
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_B_9_5.jpg
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_B_9_5.jpg
Figure 4 Liver
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_4.jpg
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_4.jpg
Figure 5 Pancreas
(Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_1_3.jpg
(Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_1_3.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_7_5.jpg
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_7_5.jpg
Figure 7 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_6_6.jpg
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_6_6.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_8.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185896-LAMP1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185896-LAMP1
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human LAMP1
- Species Reactivity
- Human
- Applications
- WB, ICC, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:2000), Immunocytochemistry (1:25), Immunohistochemistry (1:25).
Target
- Alternative Names
- LAMPA; CD107a; LGP120
- Gene ID
- 3916
- UniProt ID
- P11279
- Sequence Similarities
- Belongs to the LAMP family.
- Cellular Localization
- Cell membrane, Endosome, Lysosome, Membrane
- Post Translation Modifications
- O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.
- Protein Refseq
- NP_005552.3
- Function
- Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisBy Similarity3 Publications
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).2 Publications
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LAMP1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611 | Recombinant Anti-human LAMP1 Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-611 | Recombinant Human Anti-human LAMP1 Antibody | WB, IF, FuncS | IgG |
| MRO-0916-CN | Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (JJ0940) | WB, IHC | Rabbit IgG |
| VS3-FY835 | Recombinant Mouse Anti-LAMP1 Antibody (clone 1D7C1) | ELISA, WB, IHC, ICC, FC | Mouse IgG1 |
| VS3-FY836 | Recombinant Mouse Anti-LAMP1 Antibody (clone 4D2A6) | ELISA, IHC, FC | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611-F(E) | Recombinant Anti-human LAMP1 Antibody Fab Fragment | IF, FuncS | Fab |
| MHH-611-F(E) | Recombinant Human Anti-human LAMP1 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| HPAB-0035-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0035-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0036-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0036-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0037-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0037-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611-S(P) | Recombinant Anti-human LAMP1 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-611-S(P) | Recombinant Human Anti-human LAMP1 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-0035-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0035-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0036-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0036-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0037-LSX-S(P) | Mouse Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0037-LSX-S(P)) | ELISA, IHC | Mouse scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2010 | Hi-Affi™ Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (DS2010AB) | WB, IHC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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