AbPlus™ Anti-MAPK1 Magnetic Beads (VS-0724-YC1354)
CAT#: VS-0724-YC1354
The AbPlus Anti-MAPK1 Magnetic Beads (VS-0724-YC1354) is an innovative affinity resin which is bound with anti-MAPK1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of MAPK1 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79930/1999_H7_3_selected.jpg
Subcellular Location
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal and glial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3995/12643_B_9_5_selected.jpg
Subcellular Location
Figure 3 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/21384_B_7_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/21384_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_7_4.jpg
Normal Tissue
Figure 7 Pancreas
Exocrine glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Pancreatic endocrine cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_2_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_5.jpg
Normal Tissue
Figure 9 Testis
Cells in seminiferous ducts
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_6_6.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100030-MAPK1
❮
❯
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-MAPK1 specific antibody
- Target
- MAPK1
- Immunogen
- Recombinant human ERK2/MAPK1/MAPK2, aa 1-360.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
- Alternative Names
- Mitogen-Activated Protein Kinase 1; Extracellular Signal-Regulated Kinase 2; Mitogen-Activated Protein Kinase 2; MAP Kinase Isoform P42; MAP Kinase 1; MAP Kinase 2; EC 2.7.11.24; P42-MAPK; MAPK 2; PRKM1; PRKM2; ERK-2; ERK2;
- Gene ID
- 5594
- UniProt ID
- P28482
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Related Signaling Pathways
FcεR1 Signaling Pathway
TCR Signaling Pathway
Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MAPK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0829CL | Anti-Human MAPK1 Recombinant Antibody (VB22B) | ELISA | |
| TAB-0829CL-S(P) | Anti-Human MAPK1 Recombinant Antibody scFv Fragment (VB22B) | ELISA | |
| TAB-0829CL-F(E) | Anti-Human MAPK1 Recombinant Antibody Fab Fragment (VB22B) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0695CT | Recombinant Mouse anti-Human MAPK1 Monoclonal antibody (4G9) | ELISA, FC, WB | |
| VS3-CJ844 | Mouse Anti-MAPK1 Recombinant Antibody (VS3-CJ844) | WB | Mouse IgG1, κ |
| VS3-CJ845 | Rabbit Anti-MAPK1 Recombinant Antibody (VS3-CJ845) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS3-WK1581 | Mouse Anti-MAPK1 Recombinant Antibody (clone 1H4) | WB, IHC-P, IF | Mouse IgG |
| VS7-0425-WR549 | Mouse Anti-MAPK1 Monoclonal Antibody (clone 3F8) | WB, IHC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0341MZ | Chicken Anti-MAPK1 Polyclonal IgY | WB | Chicken antibody |
| BRD-0899MZ | Chicken Anti-ERK2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC208 | PE-H-2Kd/Human Erk2 K136Q (QYIHSANVL) MHC Tetramer | FCM | |
| MHC-LC209 | APC-H-2Kd/Human Erk2 K136Q (QYIHSANVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2148 | Hi-Affi™ Recombinant Rabbit Anti-MAPK1 Monoclonal Antibody (DS2148AB) | WB, IHC-P, ICC, FC, IP | IgG |
| MOR-2155 | Hi-Affi™ Recombinant Rabbit Anti-MAPK3; MAPK1 Monoclonal Antibody (DS2155AB) | WB, IHC-P, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY191 | Mouse Anti-NHP MAPK1 Recombinant Antibody (clone 4C11) | WB, IHC, IF, ELISA | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC691 | CytoStream™ Rabbit Anti-MAPK1 Recombinant Antibody (VS13-YC691) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4224 | Anti-MAPK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4225 | Anti-Mouse MAPK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4226 | Anti-Canine MAPK1 Immunohistochemistry Kit | IHC |
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