Rabbit Anti-MAPK14 Recombinant Antibody (VS3-FY2794)
CAT#: VS3-FY2794
The anti-MAPK14 product is a rabbit recombinant monoclonal antibody that is created to recognize human MAPK14 protein. This monoclonal antibody is suitable for conducting research on Chlamydia and Coffin-Lowry Syndrome. The optimal dilution for this antibody is Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51825/834_A12_2_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_8.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_6_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112062-MAPK14
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| Sub Cat | Species Reactivity | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2941 | Human | Immunoprecipitation, Western Blot |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 |
||||||
| VS3-FY2795 | Human, Rat, Hamster | Western Blot | Western Blot: 1/500-1/1000 |
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MAPK14
- Conjugate
- Unconjugated, FITC
- Related Disease
- Chlamydia and Coffin-Lowry Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase P38 Alpha; MAX-Interacting Protein 2; CSAID-Binding Protein; MAP Kinase P38 Alpha; P38 MAP Kinase; MAP Kinase 14; EC 2.7.11.24; SAPK2A; CSBP1; CSBP2; CSPB1; CSBP; Mxi2; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein
- Gene ID
- 1432
- UniProt ID
- Q16539
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- Acetylated at Lys-53 and Lys-152 by KAT2B and EP300.
Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity.
Lys-53 and Lys-152 are deacetylated by HDAC3.
- Protein Refseq
- XP_011512612.2; XP_016865788.1; XP_016865789.1; XP_047274188.1
- Function
- MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53.
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Related Signaling Pathways
FcεR1 Signaling Pathway
TCR Signaling Pathway
Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "MAPK14"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0512MZ | Chicken Anti-RK Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2153 | Hi-Affi™ Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (DS2153AB) | ELISA, WB | IgG |
| MOR-4696 | Hi-Affi™ Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (TH210DS) | WB, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2025-CN | Rabbit Anti-MAPK14 Polyclonal Antibody (MRO-2025-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0339C | Mouse Anti-MAPK14 Recombinant Antibody (ZG-0339C) | WB | Mouse IgG |
| VS3-QX734 | Mouse Anti-MAPK14 Recombinant Antibody (clone 6F5-8A4-6G10) | IHC | Mouse IgG1 |
| VS3-QX735 | Mouse Anti-MAPK14 Recombinant Antibody (clone 8B3-4H8-6A8) | IHC | Mouse IgG1 |
| VS3-QX736 | Mouse Anti-MAPK14 Recombinant Antibody (clone 5A1-C5-F11) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1292 | AbPlus™ Anti-MAPK14 Magnetic Beads (VS-0724-YC1292) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4233 | Anti-MAPK14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4234 | Anti-Mouse MAPK14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4235 | Anti-Rat MAPK14 Immunohistochemistry Kit | IHC |
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