Rabbit Anti-MAPK14 Recombinant Antibody (VS3-FY2794) (CAT#: VS3-FY2794)
The anti-MAPK14 product is a rabbit recombinant monoclonal antibody that is created to recognize human MAPK14 protein. This monoclonal antibody is suitable for conducting research on Chlamydia and Coffin-Lowry Syndrome. The optimal dilution for this antibody is Western Blot (1/500-1/1000).
| Sub Cat | Species Reactivity | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2941 | Human | Immunoprecipitation, Western Blot |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 |
||||||
| VS3-FY2795 | Human, Rat, Hamster | Western Blot | Western Blot: 1/500-1/1000 |
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51825/834_A12_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51825/834_A12_2_selected.jpg
Figure 2 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_8.jpg
Figure 3 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_7_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_5.jpg
Figure 5 Testis
(Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_6_6.jpg
(Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_6_6.jpg
Figure 6 Bone marrow
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_B_5_4.jpg
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_B_5_4.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112062-MAPK14
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112062-MAPK14
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MAPK14
- Conjugate
- Unconjugated, FITC
- Related Disease
- Chlamydia and Coffin-Lowry Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase P38 Alpha; MAX-Interacting Protein 2; CSAID-Binding Protein; MAP Kinase P38 Alpha; P38 MAP Kinase; MAP Kinase 14; EC 2.7.11.24; SAPK2A; CSBP1; CSBP2; CSPB1; CSBP; Mxi2; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein
- Gene ID
- 1432
- UniProt ID
- Q16539
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- Acetylated at Lys-53 and Lys-152 by KAT2B and EP300.
Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity.
Lys-53 and Lys-152 are deacetylated by HDAC3.
- Protein Refseq
- XP_011512612.2; XP_016865788.1; XP_016865789.1; XP_047274188.1
- Function
- MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
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TCR Signaling Pathway
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1575z | Mouse Anti-MAPK14 Recombinant Antibody (clone 10H1) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MRO-0963-CN | Recombinant Mouse Anti-MAPK14 Monoclonal Antibody (9-B9) | WB, IF, IHC | Mouse IgG2a |
| MOB-0151F | Mouse Anti-MAPK14 Recombinant Antibody (clone 1G1) | IHC-P, IF | Mouse IgG |
| MOB-0152F | Mouse Anti-MAPK14 Recombinant Antibody (clone 8C11) | IHC-P, IF | Mouse IgG |
| ZG-0050U | Rabbit Anti-MAPK14 Recombinant Antibody (clone 6H12) | ELISA, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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