AibGenesis™ Rabbit Anti-MCM7 Recombinant Antibody (AibG-Rb-CM7250)
CAT#: VS14-YC451
Resulting from cutting-edge neural network modeling, this mAb showcases a high kinetic profile for MCM7 detection in multiple species. MCM7 is a critical catalytic subunit of the MCM2-7 hexameric complex, serving as the "partner" to MCM4 and MCM6 in the core helicase engine. It is essential for the initiation and elongation of DNA replication, acting as a primary receiver of ATR-mediated checkpoint signaling. MCM7 facilitates the transition from the inactive double-hexamer to the active CMG (Cdc45-MCM-GINS) complex, ensuring that DNA unwinding is strictly coupled to the cell cycle via the pRb-E2F signaling axis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3898/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2163/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/if_selected.jpg
Normal Tissue
Figure 4 Tonsil
High expression in tonsil
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3898/10901_A_5_8_selected.jpg
Normal Tissue
Figure 5 Bone marrow
High expression in bone marrow
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/37227_B_5_4_val_selected.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/37227_A_8_3.jpg
Normal Tissue
Figure 7 Kidney
Distal tubules Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/37227_A_9_5.jpg
Normal Tissue
Figure 8 Skin
Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Strong Quantity: <25% Endothelial cells Staining: High Intensity: Strong Fibrohistiocytic cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/37227_B_7_1.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16312/37227_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166508-MCM7
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- MCM7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-CM7250
- Applications
- Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% Glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1/500-1/2000
Immunohistochemistry (IHC): 1/50-1/200
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Target
- Alternative Names
- Minichromosome Maintenance Complex Component 7; Protein Phosphatase 1, Regulatory Subunit 104; CDC47 Homolog; P1.1-MCM3; CDC47; MCM2; MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae); Minichromosome Maintenance Deficient (S. Cerevisiae) 7; Minichromosome Maintenance Deficient 7;
- Gene ID
- 4176
- UniProt ID
- P33993
- Long Name
- Minichromosome Maintenance Complex Component 7
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MCM7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0743CL | Mouse Anti-MCM7 Recombinant Antibody (TAB-0743CL) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0743CL-S(P) | Mouse Anti-MCM7 Recombinant Antibody; scFv Fragment (TAB-0743CL-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0743CL-F(E) | Mouse Anti-MCM7 Recombinant Antibody; Fab Fragment (TAB-0743CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1147CT | Recombinant Mouse anti-Human MCM7 Monoclonal antibody (EDT-252) | ICC, IF, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2194 | Hi-Affi™ Recombinant Rabbit Anti-MCM7 Monoclonal Antibody (DS2194AB) | ICC, IF, WB, IP, ICC, FC, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY913 | Recombinant Rabbit Anti-MCM7 Antibody (clone R07-7A4) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1324 | Anti-MCM7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4314 | Anti-Human MCM7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0426-FY570 | AibGenesis™ Rabbit Anti-MCM7 Recombinant Antibody (AibG-Rb-MC570) | WB, IHC, ICC, IF, FC, IP | Rabbit IgG |
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