Anti-MMP14 (clone LEM-2/15) Recombinant Antibody Coupled Liposome (VS-1024-FY260)
CAT#: VS-1024-FY260
The anti-MT1-MMP (Fab') stealth liposomes loaded with doxorubicin (DOX) showed significantly better pharmacological activity compared to non-targeted stealth liposomes. The accumulation of both types in the tumor primarily relies on the "enhanced permeability and retention effect" (EPR effect). The EPR effect facilitates better accumulation of appropriately sized drug carriers within tumor tissues.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to cytosol & intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/1591_G3_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong luminal membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/134761_A_8_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows positivity in stromal cells and plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to cytosol & intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/1658_G1_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_6_6.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (ASC diff, HHSteC, HSkMC, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157227-MMP14
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- LEM-2/15
- Antibody Type
- Fab
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The antibody is a mouse monoclonal antibody that binds to the hemopexin (Hpx) domain of MT1-MMP. It was generated through immunization with the recombinant Hpx domain of MT1-MMP.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MMP14
- Introduction
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
- Alternative Names
- Matrix Metallopeptidase 14; Matrix Metallopeptidase 14 (Membrane-Inserted); Membrane-Type-1 Matrix Metalloproteinase; Membrane Type 1 Metalloprotease; EC 3.4.24.80; MT-MMP 1; MT1-MMP; MMP-14; MMP-X1
- Full Name
- Matrix Metallopeptidase 14
- Gene ID
- 4323
- UniProt ID
- P50281
- Sequence Similarities
- Belongs to the peptidase M10A family.
- Cellular Localization
- Cytoplasm, Membrane
- Post Translation Modifications
- The precursor is cleaved by a furin endopeptidase.
Tyrosine phosphorylated by PKDCC/VLK.
- Protein Refseq
- NP_004986.1
- Function
- Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity).
May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484).
Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657).
Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-865-VHH | Recombinant Anti-human MMP14 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-665-S(P) | Recombinant Anti-human MMP14 Antibody scFv Fragment | FC, Neut, Funcs | scFv |
| MHH-665-S(P) | Recombinant Human Anti-human MMP14 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| PSBL-279 | Mouse Anti-MMP14 Recombinant Antibody (clone LEM-2/15); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0887-FY-F(E) | Mouse Anti-MMP14 Recombinant Antibody (clone 66C); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0888-FY-F(E) | Mouse Anti-MMP14 Recombinant Antibody (clone 19B); scFv Fragment | ELISA, IA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-665 | Recombinant Human Anti-human MMP14 Antibody | ELISA, WB, FC, FuncS | IgG |
| HPAB-1316-FY | Human Anti-MMP14 Recombinant Antibody (HPAB-1316-FY) | Activ | Human IgG |
| HPAB-1317-FY | Human Anti-MMP14 Recombinant Antibody (clone M0030-A04) | ELISA | Human IgG |
| HPAB-1318-FY | Human Anti-MMP14 Recombinant Antibody (clone M0030-D08) | ELISA | Human IgG |
| HPAB-1319-FY | Human Anti-MMP14 Recombinant Antibody (clone M0031-A02) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-531CL | Human Anti-MMP14 Recombinant Antibody (TAB-531CL) | FuncS | Human IgG |
| TAB-0822CL | Human Anti-MMP14 Recombinant Antibody (TAB-0822CL) | ELISA, FuncS, FC, IHC | Human IgG |
| TAB-0823CL | Human Anti-MMP14 Recombinant Antibody (TAB-0823CL) | ELISA | Human IgG |
| TAB-0822CL-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (TAB-0822CL-S(P)) | ELISA, FC, IHC | Human scFv |
| TAB-0823CL-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (TAB-0823CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0370MZ | Chicken Anti-MMP14 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2251 | Hi-Affi™ Recombinant Rabbit Anti-MMP14 Monoclonal Antibody (DS2251AB) | IHC-P, ICC, IF, FC, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260CQ-F(E) | Human Anti-MMP14 Recombinant Antibody; Fab Fragment (HPAB-0260CQ-F(E)) | ELISA, FC, IHC | Human Fab |
| HPAB-1316-FY-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (HPAB-1316-FY-S(P)) | Activ | Human scFv |
| HPAB-1317-FY-S(P) | Human Anti-MMP14 Recombinant Antibody (clone M0030-A04); Fab Fragment | ELISA | Human Fab |
| HPAB-1318-FY-S(P) | Human Anti-MMP14 Recombinant Antibody (clone M0030-D08); Fab Fragment | ELISA | Human Fab |
| HPAB-1319-FY-S(P) | Human Anti-MMP14 Recombinant Antibody (clone M0031-A02); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ1005 | Mouse Anti-MMP14 (C-Terminus) Recombinant Antibody (VS3-CJ1005) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC295 | Recombinant Anti-MMP14 Vesicular Antibody, EV Displayed (VS-0425-YC295) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4447 | Anti-MMP14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4448 | Anti-Mouse MMP14 Immunohistochemistry Kit | IHC |
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