Recombinant Anti-MMP14 Vesicular Antibody, EV Displayed (VS-0425-YC295)
CAT#: VS-0425-YC295
The Recombinant Anti-MMP14 Vesicular Antibody, EV Displayed (VS-0425-YC295) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MMP14-expressed cells or tissues. The MMP14 is a membrane-type metalloproteinase activating MMP2, which is involved in the breakdown of the extracellular matrix and processes like tumor invasion.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to cytosol & intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/1591_G3_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong luminal membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/134761_A_8_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows positivity in stromal cells and plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to cytosol & intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51432/1658_G1_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9918/24805_A_6_6.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (ASC diff, HHSteC, HSkMC, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157227-MMP14
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MMP14
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Matrix metallopeptidase 14
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Cytosol, Intermediate filaments
- Introduction
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
- Alternative Names
- MT1-MMP
- Gene ID
- 4323
- UniProt ID
- P50281
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0624-WJ-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (HPAB-0624-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0625-WJ-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (HPAB-0625-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-531CL | Human Anti-MMP14 Recombinant Antibody (TAB-531CL) | FuncS | Human IgG |
| TAB-0822CL | Human Anti-MMP14 Recombinant Antibody (TAB-0822CL) | ELISA, FuncS, FC, IHC | Human IgG |
| TAB-0823CL | Human Anti-MMP14 Recombinant Antibody (TAB-0823CL) | ELISA | Human IgG |
| TAB-0822CL-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (TAB-0822CL-S(P)) | ELISA, FC, IHC | Human scFv |
| TAB-0823CL-S(P) | Human Anti-MMP14 Recombinant Antibody; scFv Fragment (TAB-0823CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0370MZ | Chicken Anti-MMP14 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2251 | Hi-Affi™ Recombinant Rabbit Anti-MMP14 Monoclonal Antibody (DS2251AB) | IHC-P, ICC, IF, FC, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1010-CN | Recombinant Rabbit Anti-MMP14 Monoclonal Antibody (CBACN-377) | WB, IF, IHC, IP, FC | Rabbit IgG |
| HPAB-0887-FY | Mouse Anti-MMP14 Recombinant Antibody (clone 66C) | ELISA | Mouse IgG |
| HPAB-0888-FY | Mouse Anti-MMP14 Recombinant Antibody (clone 19B) | ELISA, IA | Mouse IgG |
| HPAB-0889-FY | Mouse Anti-MMP14 Recombinant Antibody (clone MMP98) | ELISA | Mouse IgG |
| VS3-FY938 | Recombinant Rabbit Anti-MMP14 Antibody (clone R05-6H5) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ1005 | Mouse Anti-MMP14 (C-Terminus) Recombinant Antibody (VS3-CJ1005) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4447 | Anti-MMP14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4448 | Anti-Mouse MMP14 Immunohistochemistry Kit | IHC |
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