Human Anti-NGF Recombinant Antibody (clone MEDI578) (CAT#: PABC-401)
This product is a recombinant Human antibody that can recognize NGF. MEDI-578 is a phage display derived anti-NGF antibody with a KD of 69 pM.
Specific Inquiry
FuncS
Figure 1 Effects of the anti-NGF antibody MEDI-578 on FCA-induced changes in guarding index.
When the behavioural effects had been assessed 24 h after FCA injection, the antibody was injected intravenously, and behaviour subsequently tested once daily. In (A) results plotted over time from two studies with complementing doses are shown in black and grey symbols and lines, and in (B), for clarification, the relative normalising effects of all doses compared to the vehicle group at 100% on day 3 are shown.
Möller, K. Ä., Berge, O. G., Finn, A., Stenfors, C., & Svensson, C. I. (2015). Using gait analysis to assess weight bearing in rats with Freund׳ s complete adjuvant-induced monoarthritis to improve predictivity: Interfering with the cyclooxygenase and nerve growth factor pathways. European journal of pharmacology, 756, 75-84.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1
- Specificity
- Human NGF
- Species Reactivity
- Human
- Clone
- MEDI578
- Applications
- FuncS, ELISA, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody MEDI578 has been reported in applications of Functional Assay, Enzyme-linked Immunosorbent Assay and Immunohistochemistry. It is recommended that the optimal antibody concentration, dilution, incubation time, etc. should be carefully titrated in a specific assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-110 | Human Anti-NGF Recombinant Antibody (TAB-110) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Human IgG2, κ |
| TAB-244 | Anti-Human HNGF Recombinant Antibody | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG4 - kappa |
| TAB-512MZ-S(P) | Human Anti-NGF Recombinant Antibody; scFv Fragment (TAB-512MZ-S(P)) | ELISA, RIA, FC | Human scFv |
| TAB-512MZ-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-512MZ-F(E)) | ELISA, RIA, FC | Human Fab |
| TAB-513MZ-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-513MZ-F(E)) | ELISA, RIA, FC | Human Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111 | Anti-Human NGF Recombinant Antibody (Tanezumab) | ELISA, FuncS, Inhib | IgG2 |
| TAB-686CL | Anti-Human NGF Therapeutical Antibody (PG110) | FuncS | Antibody |
| TAB-501MZ | Anti-Human NGF Recombinant Antibody (αD11. H67) | ELISA | Humanized antibody |
| TAB-501MZ-S(P) | Anti-Human NGF Recombinant Antibody scFv Fragment (αD11. H67) | ELISA, IRMA, RIA, IHC | Humanized antibody |
| TAB-501MZ-F(E) | Anti-Human NGF Recombinant Antibody Fab Fragment (αD11. H67) | ELISA, IRMA, RIA, IHC | Humanized antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-659 | Human Anti-NGF Recombinant Antibody (clone APE1531); Fab Fragment | WB, FuncS | Human Fab |
| PFBC-234 | Human Anti-NGF Recombinant Antibody (clone APE1551); Fab Fragment | ELISA, WB | Human Fab |
| FAMAB-0027-YC-F(E) | Rat Anti-NGF Recombinant Antibody (clone G 24); Fab Fragment | WB | Rat Fab |
| FAMAB-0028-YC-F(E) | Rat Anti-NGF Recombinant Antibody (clone G 30); Fab Fragment | WB, ICC, FuncS | Rat Fab |
| HPAB-0688-CN-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (HPAB-0688-CN-F(E)) | WB, ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0331CL | Mouse Anti-NGF Recombinant Antibody (TAB-0331CL) | Neut, ELISA, Inhib, FuncS | Mouse IgG |
| TAB-500MZ | Anti-Human NGF Recombinant Antibody (MNAC13) | ELISA, IRMA, RIA, IHC | |
| TAB-502MZ | Anti-Dog NGF Recombinant Antibody (NV-01) | SDS-PAGE | |
| TAB-503MZ | Mouse Anti-NGF Recombinant Antibody (TAB-503MZ) | ELISA | Mouse IgG |
| TAB-504MZ | Mouse Anti-NGF Recombinant Antibody (TAB-504MZ) | ELISA | Mouse IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-509MZ | Human Anti-NGF Recombinant Antibody (TAB-509MZ) | ELISA | Chimeric (mouse/human) IgG |
| TAB-509MZ-S(P) | Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-509MZ-S(P)) | ELISA | Mouse scFv |
| TAB-510MZ-S(P) | Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-510MZ-S(P)) | ELISA | Mouse scFv |
| TAB-509MZ-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-509MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-510MZ-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-510MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0852MZ | Chicken Anti-NGF Polyclonal IgY | ELISA | Chicken antibody |
| BRD-1134MZ | Chicken Anti-Beta NGF Polyclonal IgY | ELISA, WB, IHC | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-146-S (P) | Rat Anti-NGF Recombinant Antibody (clone αD11) | Neut, FC, FuncS | Rat scFv |
| MOR-2439 | Hi-Affi™ Recombinant Rabbit Anti-NGF Monoclonal Antibody (DS2439AB) | WB, ICC, IHC-P, IHC-P | IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1764CQ | Recombinant Mouse Anti-NGF Antibody (CBL293) | Neut | IgG1 |
| NEUT-1774CQ | Recombinant Rabbit Anti-NGF Antibody (CBL1010) | Neut | IgG |
| NEUT-1775CQ | Recombinant Mouse Anti-NGF Antibody (CBL147) | ELISA, Neut | IgG1 |
| NEUT-1776CQ | Recombinant Mouse Anti-NGF Antibody (CBL941) | ELISA, Neut, WB | IgG2b, κ |
| NEUT-1777CQ | Recombinant Mouse Anti-Ngf Antibody (CBL836) | Neut | IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1768CQ | Recombinant Mouse Anti-NGF Antibody (aD11) | IF, BL, ELISA, IHC | IgG1, κ |
| NEUT-1772CQ | Recombinant Mouse Anti-NGF Antibody (25623.1) | Dot, ELISA, Inhib | IgG1 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0027YC | Rat Anti-NGF Recombinant Antibody (clone G 24) | WB | Rat IgG2a |
| HPAB-AP153-YC | Canine Anti-NGF Recombinant Antibody (HPAB-AP153-YC) | ELISA, FuncS | Canine IgG |
| HPAB-AP154-YC | Canine Anti-NGF Recombinant Antibody (HPAB-AP154-YC) | ELISA, FuncS | Canine IgG |
| HPAB-AP155-YC | Canine Anti-NGF Recombinant Antibody (HPAB-AP155-YC) | ELISA, FuncS | Canine IgG |
| FAMAB-1225CQ | Mouse Anti-NGF Recombinant Antibody (clone alphaD11) | Block, ELISA, IF, IHC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-401 | Human Anti-NGF Recombinant Antibody (clone MEDI578); scFv Fragment | ELISA, IHC | Human scFv |
| HPAB-N0190-YC-S(P) | Human Anti-NGF Recombinant Antibody (clone NOV009YC); scFv Fragment | ELISA | Human scFv |
| HPAB-N0191-YC-S(P) | Human Anti-NGF Recombinant Antibody (clone G11-H2L2); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-1789-FY-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (HPAB-1789-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-1790-FY-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (HPAB-1790-FY-F(E)) | ELISA, IHC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-025ML | Afuco™ Anti-NGF ADCC Recombinant Antibody (Frunevetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-031ML | Afuco™ Anti-NGF ADCC Recombinant Antibody (Ranevetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-111 | Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-110 | Afuco™ Anti-NGF Recombinant Antibody (AFC-TAB-110), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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