Anti-NTRK3 Antibody Prodrug, Protease Activated (VS-1025-YC58)
CAT#: VS-1025-YC58
The Anti-NTRK3 Antibody Prodrug, Protease Activated (VS-1025-YC58) is an antibody prodrug comprised of a recombinant human antibody targeting human and rat NTRK3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to NTRK3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to NTRK3 effectively. NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) is a receptor tyrosine kinase that becomes a highly significant, targetable oncogene when its gene is fused with another partner gene, most notably ETV6-NTRK3, due to a chromosomal translocation. The resulting constitutively active TRK fusion protein drives relentless growth signals across a diverse array of solid tumors, including mammary analogue secretory carcinoma (MASC) and a subset of lung and thyroid cancers. This activation pathway is exquisitely sensitive to specific TRK inhibitors, providing an effective treatment strategy for patients with these molecularly defined cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoli & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27484/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48065/if_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_B_7_5.jpg
Normal Tissue
Figure 4 Colon
nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_8_3.jpg
Normal Tissue
Figure 5 Testis
nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (U-138 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000140538-NTRK3
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human and Rat NTRK3
- Target
- NTRK3
- Species Reactivity
- Human, Rat
- Isotype
- IgG2a, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
- Alternative Names
- TRKC; GP145-TrkC; gp145(trkC)
- Gene ID
- 4916
- UniProt ID
- Q16288
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Related Diseases
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