Recombinant Anti-NTRK3 Vesicular Antibody, EV Displayed (VS-0425-YC221) (CAT#: VS-0425-YC221)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• NTRK3

• Host Animal
• Mouse

• Antibody Isotype
• IgG1 kappa

• Species Reactivity
• Human, Rat, Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein G

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Neurotrophic receptor tyrosine kinase 3

• Biological Process
• Differentiation, Neurogenesis

• Molecular Function
• Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Nucleoli, Nucleoli rim, Nuclear membrane

• Introduction
• This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

• Alternative Names
• TRKC

• Gene ID
• 4916

• UniProt ID
• Q16288

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