Recombinant Anti-NTRK3 Vesicular Antibody, EV Displayed (VS-0425-YC221)
CAT#: VS-0425-YC221
The Recombinant Anti-NTRK3 Vesicular Antibody, EV Displayed (VS-0425-YC221) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NTRK3-expressed cells or tissues. The NTRK3 is a tyrosine receptor kinase involved in cell differentiation, linked to cancers such as medulloblastomas. It has several transcript variants.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoli & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27484/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48065/if_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_B_7_5.jpg
Normal Tissue
Figure 4 Colon
nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_8_3.jpg
Normal Tissue
Figure 5 Testis
nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9233/30817_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (U-138 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000140538-NTRK3
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NTRK3
- Host Animal
- Mouse
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human, Rat, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Neurotrophic receptor tyrosine kinase 3
- Biological Process
- Differentiation, Neurogenesis
- Molecular Function
- Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Nucleoli, Nucleoli rim, Nuclear membrane
- Introduction
- This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
- Alternative Names
- TRKC
- Gene ID
- 4916
- UniProt ID
- Q16288
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Related Diseases
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-181CQ | Mouse Anti-NTRK3 Recombinant Antibody (TAB-181CQ) | ELISA, IF, WB, FC | Mouse IgG1, κ |
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| TAB-183CQ-F(E) | Anti-Human NTRK3 Recombinant Antibody Fab Fragment (2256) | ELISA, WB | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-182CQ | Anti-Human NTRK3 Recombinant Antibody (6.4.1) | ELISA, WB | Human antibody |
| TAB-185CQ | Anti-Human NTRK3 Recombinant Antibody (6.1.2) | ELISA, WB | Human antibody |
| TAB-182CQ-S(P) | Anti-Human NTRK3 Recombinant Antibody scFv Fragment (6.4.1) | ELISA, WB | Human antibody |
| TAB-182CQ-F(E) | Anti-Human NTRK3 Recombinant Antibody Fab Fragment (6.4.1) | ELISA, WB | Human antibody |
| TAB-185CQ-F(E) | Anti-Human NTRK3 Recombinant Antibody Fab Fragment (6.1.2) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4350 | Hi-Affi™ Recombinant Rabbit Anti-NTRK3 Monoclonal Antibody (SI440DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0198-CN-S(P) | Human Anti-NTRK3 Recombinant Antibody scFv Fragment (HPAB-0198-CN-S(P)) | ELISA, ICC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0198-CN-F(E) | Human Anti-NTRK3 Recombinant Antibody Fab Fragment (HPAB-0198-CN-F(E)) | ELISA, ICC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5023 | Anti-NTRK3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5024 | Anti-Mouse NTRK3 Immunohistochemistry Kit | IHC |
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