Anti-PDGFRA (clone 2.175.3) Recombinant Antibody Coupled Liposome (VS-1024-FY122)
CAT#: VS-1024-FY122
The anti-PDGFRα antibody-conjugated liposomes have shown good targeting ability and drug delivery efficiency in the treatment of gliomas. By targeting tumor cells that express PDGFRα, the accumulation and efficacy of the drug can be significantly enhanced while reducing damage to normal tissues. Studies have demonstrated that this technology has significant potential in inhibiting tumor growth and improving survival rates. Future clinical trials are expected to further validate its safety and efficacy, providing new treatment options for glioma patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4947/1030_B8_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Fibroblasts Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_7_5.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HHSteC, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134853-PDGFRA
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- 2.175.3
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody engineered to specifically bind to the human platelet-derived growth factor receptor alpha (PDGFRA). PDGFRA plays a critical role in various cellular processes, including cell growth, differentiation, and survival, making it an important target in the treatment of several diseases, particularly certain types of cancers and fibrotic disorders.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PDGFRA
- Introduction
- This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
- Alternative Names
- Platelet Derived Growth Factor Receptor Alpha; Platelet-Derived Growth Factor Receptor, Alpha Polypeptide; Alpha-Type Platelet-Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor 2; CD140 Antigen-Like Family Member A; CD140a Antigen; PDGF-R-Alpha; EC 2.7.10.1; PDGFR-2
- Full Name
- Platelet Derived Growth Factor Receptor Alpha
- Gene ID
- 5156
- UniProt ID
- P16234
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Cellular Localization
- Cell membrane, Cell projection, Golgi apparatus, Membrane
- Post Translation Modifications
- N-glycosylated.
Ubiquitinated, leading to its internalization and degradation.
Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.
- Protein Refseq
- NP_001334758.1; NP_006197.1
- Function
- Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
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Datasheet
MSDS
COA
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| TAB-1063CL-F(E) | Human Anti-PDGFRA Recombinant Antibody; Fab Fragment (TAB-1063CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
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| NEUT-1848CQ | Recombinant Rat Anti-Pdgfra Antibody (APA5) | FC, FuncS, IHC-Fr, Neut, WB | IgG2a, κ |
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| CAT | Product Name | Application | Type |
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| MOR-2637 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRA Monoclonal Antibody (DS2637AB) | WB | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0233LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1) | Inhib, FC | Human IgG1 |
| HPAB-0234LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3) | Inhib, FC | Human IgG1 |
| HPAB-0235LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2) | Inhib, FC | Human IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.175.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0233LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0234LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0235LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0236LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3); scfv Fragment | Inhib, FC | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.1954.2); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0245LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 3.23.2); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0246LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 3.87.1.1); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0247LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 3.341.1); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0248LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 3.472.1.1); Fab Fragment | Inhib, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-192 | Afuco™ Anti-PDGFRA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-192) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-878 | Afuco™ Anti-PDGFRA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-878) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY164 | Human Anti-PDGFRA (clone 2.175.3) scFv-Fc Chimera | Inhib, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC216 | Recombinant Anti-PDGFRA Vesicular Antibody, EV Displayed (VS-0425-YC216) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5274 | Anti-PDGFRA Immunohistochemistry Kit | IHC | |
| VS-0525-XY5275 | Anti-Mouse PDGFRA Immunohistochemistry Kit | IHC | |
| VS-0525-XY5276 | Anti-Rat PDGFRA Immunohistochemistry Kit | IHC |
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