Anti-PTEN (clone W24V123) Recombinant Antibody Coupled Liposome (VS-1024-FY125)
CAT#: VS-1024-FY125
Anti-PTEN antibodies conjugated with liposomes have shown great potential in the treatment of gliomas. Some studies indicate that the use of these liposomes can effectively inhibit tumor growth, achieving up to 90% tumor reduction. Moreover, the activity of PTEN is closely related to the sensitivity of glioma cells to radiotherapy, suggesting that anti-PTEN antibodies may play an important role in enhancing therapeutic efficacy.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V123
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been designed to selectively bind to human PTEN, a crucial tumor suppressor protein. By targeting PTEN, this antibody can be instrumental in various research applications, including cancer studies and the investigation of signaling pathways. Its specificity for human PTEN makes it an invaluable tool for scientists aiming to explore the role of this protein in human diseases and to develop potential therapeutic strategies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PTEN
- Introduction
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
- Alternative Names
- BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
- Full Name
- Phosphatase and tensin homolog
- Gene ID
- 5728
- UniProt ID
- P60484
- Sequence Similarities
- Belongs to the PTEN phosphatase protein family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Constitutively phosphorylated by CK2 under normal conditions.
Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11.
Phosphorylation results in an inhibited activity towards PIP3.
Phosphorylation can both inhibit or promote PDZ-binding.
Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4.
Phosphorylation by ROCK1 is essential for its stability and activity.
Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome.
Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1.
- Protein Refseq
- NP_000305.3; NP_001291646.4; NP_001291647.1
- Function
- Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, 9256433, 9616126).
Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3.
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Related Diseases
Endometrial Cancer
Related Signaling Pathways
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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Lot Number:
- CAT
- Product Name
See other products for "PTEN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B021(A) | Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B021(G) | Recombinant Anti-mouse PTEN Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
| IAB-B021(T) | Recombinant Anti-mouse PTEN Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2915 | Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) | ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0527U | Rabbit Anti-Phospho-PTEN (S380) Recombinant Antibody (clone 4D10) | ELISA, WB | Rabbit IgG |
| VS3-QX925 | Mouse Anti-PTEN Recombinant Antibody (clone 4G4-4H9-1E10) | IHC | Mouse IgG1 |
| VS3-QX926 | Mouse Anti-PTEN Recombinant Antibody (clone 7H2-6G9-6H5) | IHC | Mouse IgG1 |
| VS3-QX927 | Mouse Anti-PTEN Recombinant Antibody (clone 1B8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ1061 | Mouse Anti-PTEN Recombinant Antibody (VS3-CJ1061) | WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY183 | CytoStream™ Mouse Anti-PTEN Recombinant Antibody (VS-0225-XY183) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1816 | Anti-PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5823 | Anti-Mouse PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5822 | Anti-Human PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5824 | Anti-Rat PTEN Immunohistochemistry Kit | IHC |
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