Anti-PTEN (clone W24V222) Recombinant Antibody Coupled Liposome (VS-1024-FY219)
CAT#: VS-1024-FY219
Anti-PTEN antibody-conjugated liposomes have shown significant potential in ovarian cancer research. By targeting cells with PTEN expression deficiency, these liposomes can effectively enhance the selectivity and targeting of drugs. Studies indicate that anti-PTEN antibody-conjugated liposomes demonstrate significant improvements in drug delivery and therapeutic effects compared to traditional methods. This strategy may provide new treatment options for ovarian cancer patients and promote the development of personalized medicine.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Ovarian cancer
Product Composition
- Clone
- W24V222
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that was designed for specific binding to PTEN, a pivotal tumor suppressor that regulates cell growth and apoptosis. Targeting PTEN can help elucidate its role in cellular signaling pathways and its implications in various cancers, particularly in those cases with PTEN loss or mutations. This high-specificity antibody offers valuable opportunities for collaborative research aimed at deciphering tumor biology and exploring new cancer treatment avenues.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PTEN
- Introduction
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
- Alternative Names
- BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
- Full Name
- Phosphatase and tensin homolog
- Gene ID
- 5728
- UniProt ID
- P60484
- Sequence Similarities
- Belongs to the PTEN phosphatase protein family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Constitutively phosphorylated by CK2 under normal conditions.
Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11.
Phosphorylation results in an inhibited activity towards PIP3.
Phosphorylation can both inhibit or promote PDZ-binding.
Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4.
Phosphorylation by ROCK1 is essential for its stability and activity.
Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome.
Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1.
- Protein Refseq
- NP_000305.3; NP_001291646.4; NP_001291647.1
- Function
- Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, 9256433, 9616126).
Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3.
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Related Diseases
Endometrial Cancer
Related Signaling Pathways
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
- CAT
- Product Name
See other products for "PTEN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1640z | Mouse Anti-PTEN Recombinant Antibody (clone 27C11) | WB, ELISA, FC, ICC, IF | Mouse IgG1 |
| MRO-2365-CN | Recombinant Rabbit Anti-PTEN (phosphorylated Ser380) Monoclonal Antibody (CBACN-651) | WB, IF | Rabbit IgG |
| MOB-0231F | Mouse Anti-PTEN Recombinant Antibody (clone 2C10) | IHC-P, IF | Mouse IgG |
| MOB-0232F | Mouse Anti-PTEN Recombinant Antibody (clone 9E8) | IHC-P, IF | Mouse IgG |
| VS13-YC954 | Rabbit Anti-PTEN Recombinant Antibody (VS13-YC954) | WB, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B021(A) | Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B021(G) | Recombinant Anti-mouse PTEN Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
| IAB-B021(T) | Recombinant Anti-mouse PTEN Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2915 | Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) | ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY183 | CytoStream™ Mouse Anti-PTEN Recombinant Antibody (VS-0225-XY183) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1816 | Anti-PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5823 | Anti-Mouse PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5822 | Anti-Human PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5824 | Anti-Rat PTEN Immunohistochemistry Kit | IHC |
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