Anti-PTEN (clone W24V222) Recombinant Antibody Coupled Liposome (VS-1024-FY219) (CAT#: VS-1024-FY219)

• Potential Clinical Applications
• Ovarian cancer

• Clone
• W24V222

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This antibody is a recombinant mouse monoclonal that was designed for specific binding to PTEN, a pivotal tumor suppressor that regulates cell growth and apoptosis. Targeting PTEN can help elucidate its role in cellular signaling pathways and its implications in various cancers, particularly in those cases with PTEN loss or mutations. This high-specificity antibody offers valuable opportunities for collaborative research aimed at deciphering tumor biology and exploring new cancer treatment avenues.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• PTEN

• Introduction
• This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.

• Alternative Names
• BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta

• Full Name
• Phosphatase and tensin homolog

• Gene ID
• 5728

• UniProt ID
• P60484

• Sequence Similarities
• Belongs to the PTEN phosphatase protein family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Constitutively phosphorylated by CK2 under normal conditions.
  Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11.
  Phosphorylation results in an inhibited activity towards PIP3.
  Phosphorylation can both inhibit or promote PDZ-binding.
  Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4.
  Phosphorylation by ROCK1 is essential for its stability and activity.
  Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome.
  Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1.

• Protein Refseq
• NP_000305.3; NP_001291646.4; NP_001291647.1

• Function
• Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, 9256433, 9616126).
  Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3.

• VS-1024-FY125
• Anti-PTEN (clone W24V123) Recombinant Antibody Coupled Liposome (VS-1024-FY125)

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