Rabbit Anti-PTPRC Recombinant Antibody (clone R08-2H1) (CAT#: VS3-XY3482)
This product is a recombinant rabbit antibody binding to PTPRC (Protein tyrosine phosphatase receptor type C), which acts as a positive regulator of T-cell coactivation upon binding to DPP4. This antibody specifically recognizes human PTPRC. It has been detected by Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/50-1/100 and 1/50-1/200, respectively.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Figure 2 Appendix
(Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
(Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Figure 3 Lymph node
(Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
(Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PTPRC
- Species Reactivity
- Human
- Clone
- R08-2H1
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Immunodeficiency 105; Immunodeficiency 104
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
- Gene ID
- 5788
- UniProt ID
- P08575
- Long Name
- Protein tyrosine phosphatase receptor type C
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Heavily N- and O-glycosylated.
- Protein Refseq
- NP_002829.3; NP_563578.2
- Function
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PTPRC"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1135z | Mouse Anti-PTPRC Recombinant Antibody (clone 19C6) | WB, FC, IF, IHC | Mouse IgG2a, κ |
| MOB-0051MZ | Recombinant Mouse Anti-Human CD45 Antibody (clone A290-11242) | FC, IHC | Mouse antibody |
| FAMAB-1649CQ | Mouse Anti-PTPRC Recombinant Antibody (clone UCH-L1) | IP, WB, FC, IHC | Mouse IgG2a |
| FAMAB-1651CQ | Mouse Anti-PTPRC Recombinant Antibody (clone OX22) | IP, FC, IHC | Mouse IgG1 |
| FAMAB-1652CQ | Mouse Anti-PTPRC Recombinant Antibody (clone OX33) | ICC, IP, FC, IHC | Mouse IgG1 |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-264LC | Human Anti-PTPRC Recombinant Antibody (TAB-264LC) | ELISA, FC | Human IgG2, κ |
| TAB-245LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-245LC-F(E)) | ELISA, FC | Human Fab |
| TAB-246LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-246LC-F(E)) | ELISA, FC | Human Fab |
| TAB-247LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-247LC-F(E)) | ELISA, FC | Human Fab |
| TAB-248LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-248LC-F(E)) | ELISA, FC | Human Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-240LC-S(P) | Anti-Human PTPRC Recombinant Antibody scFv Fragment (VHE/humV1) | ELISA, FC | Humanized antibody |
| TAB-241LC-S(P) | Anti-Human PTPRC Recombinant Antibody scFv Fragment (VHE/humV2) | ELISA, FC | Humanized antibody |
| TAB-242LC-S(P) | Anti-Human PTPRC Recombinant Antibody scFv Fragment (VHQ/humV1) | ELISA, FC | Humanized antibody |
| TAB-243LC-S(P) | Anti-Human PTPRC Recombinant Antibody scFv Fragment (VHQ/humV2 ) | ELISA, FC | Humanized antibody |
| TAB-244LC-S(P) | Anti-Human PTPRC Recombinant Antibody scFv Fragment (VHE-N73D/humV1 ) | ELISA, FC | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0466MZ | Chicken Anti-PTPRC Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1895CQ | Recombinant Mouse Anti-PTPRC Antibody (HI30) | WB, IP, IHC-Fr, FuncS, ICC, FC, IHC-P, BL | IgG1 |
| NEUT-1896CQ | Recombinant Mouse Anti-Ptprc Antibody (104-2) | FC, IP, BL, IHC-Fr, ICC/IF | IgG2a, κ |
| NEUT-1897CQ | Recombinant Rat Anti-Ptprc Antibody (MAB0822) | BL, FC, IP, WB | IgG2 |
| NEUT-1898CQ | Recombinant Rat Anti-Ptprc Antibody (RA3-6B2) | FC, IHC-Fr, IHC-P, IP, WB, BL | IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2933 | Hi-Affi™ Recombinant Rabbit Anti-PTPRC Monoclonal Antibody (DS2933AB) | IP, WB | IgG |
| MOR-0089-FY | Rabbit Anti-PTPRC Recombinant Antibody (clone AFY0060) | ICC, IHC-P, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-S(P) | Rabbit Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0365-CN-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0366-CN-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0366-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0258-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0258-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-1058-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-1058-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0536-FY-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0536-FY-S(P)) | Inhib, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-F(E) | Rabbit Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0365-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0366-CN-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0366-CN-F(E)) | ELISA, FC | Humanized Fab |
| FAMAB-0006-CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); Fab Fragment | FC | Mouse Fab |
| HPAB-0258-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0258-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1058-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-1058-FY-S(P)) | ELISA, Neut | scFv |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-023CN | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4) | FC, IF | Mouse IgG1, κ |
| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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