Mouse Anti-RYK Recombinant Antibody (VS3-FY2867)
CAT#: VS3-FY2867
The anti-RYK antibody is a mouse recombinant monoclonal antibody that targets the human, mouse RYK protein. The calculated molecular weight of the protein is about 67.8 kDa. This monoclonal antibody proves valuable in disease research related to Robinow Syndrome and Norrie Disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75430/1614_E12_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows strong nuclear positivity in glial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45503/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_5_6.jpg
Normal Tissue
Figure 7 Endometrium
Cells in endometrial stroma Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_1_3.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163785-RYK
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse RYK
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot, Flow cytometry
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 67.8 kDa.
- Related Disease
- Robinow Syndrome and Norrie Disease
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Flow cytometry: 1/10-1/25
Target
- Alternative Names
- Receptor-Like Tyrosine Kinase; JTK5A Protein Tyrosine Kinase; EC 2.7.10.1; JTK5A; RYK Receptor-Like Tyrosine Kinase; Tyrosine-Protein Kinase RYK
- Gene ID
- 6259
- UniProt ID
- P34925
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Post Translation Modifications
- Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation.
Cleavage occurs during neuronal differentiation.
Glycosylation at Asn139, Asn174, Asn178, Asn182, and Asn209 (NX_P34925 [NX_P34925-1])
Modification sites at PhosphoSitePlus (P34925)
Glycosylation from GlyGen (P34925) 5 sites
- Protein Refseq
- NP_001005861.1; NP_002949.2
- Function
- May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RYK"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-375CT | Anti-Human RYK Recombinant Antibody (RWD1) | WB, IHC, ELISA | Human antibody |
| TAB-375CT-S(P) | Anti-Human RYK Recombinant Antibody scFv Fragment (RWD1) | WB, ELISA, BL. IHC, IP, FC | Human antibody |
| TAB-375CT-F(E) | Anti-Human RYK Recombinant Antibody Fab Fragment (RWD1) | WB, ELISA, BL. IHC, IP, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2415CT | Recombinant Mouse anti-Human RYK Monoclonal antibody (FQS4388) | WB | |
| HPAB-M0628-YC | Mouse Anti-RYK Recombinant Antibody (HPAB-M0628-YC) | Inhib | Mouse IgG |
| HPAB-M0629-YC | Mouse Anti-RYK Recombinant Antibody (HPAB-M0629-YC) | Inhib | Mouse IgG |
| VS3-CJ887 | Mouse Anti-RYK Recombinant Antibody (VS3-CJ887) | WB, FC | Mouse IgG1, κ |
| VS3-FY1945 | Rabbit Anti-RYK Recombinant Antibody (clone R03-4E1) | WB, IHC-Fr, IHC-P, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3148 | Hi-Affi™ Recombinant Rabbit Anti-RYK Monoclonal Antibody (DS3148AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0628-YC-S(P) | Mouse Anti-RYK Recombinant Antibody; scFv Fragment (HPAB-M0628-YC-S(P)) | Inhib | Mouse scFv |
| HPAB-M0629-YC-S(P) | Mouse Anti-RYK Recombinant Antibody; scFv Fragment (HPAB-M0629-YC-S(P)) | Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0628-YC-F(E) | Mouse Anti-RYK Recombinant Antibody; Fab Fragment (HPAB-M0628-YC-F(E)) | Inhib | Mouse Fab |
| HPAB-M0629-YC-F(E) | Mouse Anti-RYK Recombinant Antibody; Fab Fragment (HPAB-M0629-YC-F(E)) | Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC472 | Recombinant Anti-RYK Vesicular Antibody, EV Displayed (VS-0425-YC472) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6289 | Anti-RYK Immunohistochemistry Kit | IHC |
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