Recombinant Anti-SELP Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC226
This biparatopic antibody (bpAb) targets two distinct SELP epitopes via its tandem scFv arms, which bind simultaneously with high affinity. One scFv engages an epitope distant from the PSGL-1 binding site on P-selectin. In contrast, the other scFv directly binds an epitope within the PSGL-1 binding region on P-selectin, thereby competitively inhibiting P-selectin and its ligand interaction.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2145/5903_A_9_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174175-SELP
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human SELP
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- A distant epitope to the PSGL-1 binding site on P-selectin.
- Epitope 2
- An epitope on the PSGL-1 binding region on P-selectin
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, FC, IP, IF
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Selectin P
Target
- Introduction
- This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
- Alternative Names
- Selectin P; CD62
- Gene ID
- 6403
- UniProt ID
- P16109
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0258-YC-S(P) | Human Anti-SELP Recombinant Antibody (clone hu5C7.29); scFv Fragment | FC, Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260-YC-S(P) | Human Anti-SELP Recombinant Antibody (clone huPB1.3); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0258-YC-F(E) | Human Anti-SELP Recombinant Antibody (clone hu5C7.29); Fab Fragment | FC, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0259-YC-F(E) | Mouse Anti-SELP Recombinant Antibody (clone PB1.3); Fab Fragment | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260-YC-F(E) | Human Anti-SELP Recombinant Antibody (clone huPB1.3); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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