Human Anti-SELP (clone Inclacumab) scFv-Fc Chimera (CAT#: VS-0425-FY168)

• Immunogen
• CD62P transfected 300.19 cells (Human) as an immunogen.

• Host Species
• Human

• Type
• Human IgG4, scFv-Fc

• Specificity
• Human SELP

• Species Reactivity
• Human

• Clone
• Inclacumab

• Applications
• Dot Blot, ELISA

• Related Disease
• Ige Responsiveness, Atopic and Intermittent Claudication

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 10 ng/mL
  Dot Blot: 2 ng/μL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Selectin P; Platelet Activation Dependent Granule-External Membrane Protein; Selectin P (Granule Membrane Protein 140kDa, Antigen CD62); Leukocyte-Endothelial Cell Adhesion Molecule 3; CD62 Antigen-Like Family Member P; Granule Membrane Protein 140kDa; Granule Membrane Protein 140; GMP-140; LECAM3; PADGEM; GRMP; Selectin P (Granule Membrane Protein 140kD, Antigen CD62)

• Gene ID
• 6403

• UniProt ID
• P16109

• Long Name
• Selectin P

• Sequence Similarities
• Belongs to the selectin/LECAM family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn272, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect LYAM3_HUMAN (2095)
  Glycosylation from GlyGen 13 sites, 8 N-linked glycans (4 sites)

• Protein Refseq
• XP_005245492.1; XP_005245493.1; XP_005245495.1; XP_005245496.1; XP_005245497.1

• Function
• Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.
  Mediates the interaction of activated endothelial cells or platelets with leukocytes.
  The ligand recognized is sialyl-Lewis X.
  Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
  Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3.

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