Human Anti-SELP (clone Inclacumab) scFv-Fc Chimera
CAT#: VS-0425-FY168
Anti-SELP scFv-FC is a recombinant protein designed for high-affinity binding to SELP, facilitating the modulation of its biological activity. The scFv (single-chain variable fragment) consists of the variable regions of an antibody, which provides specificity for SELP, while the Fc (fragment crystallizable) region enhances stability, half-life, and initiates immune effector functions.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2145/5903_A_9_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174175-SELP
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Specifications
- Immunogen
- CD62P transfected 300.19 cells (Human) as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human SELP
- Species Reactivity
- Human
- Clone
- Inclacumab
- Applications
- Dot Blot, ELISA
- Related Disease
- Ige Responsiveness, Atopic and Intermittent Claudication
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 10 ng/mL
Dot Blot: 2 ng/μL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Selectin P; Platelet Activation Dependent Granule-External Membrane Protein; Selectin P (Granule Membrane Protein 140kDa, Antigen CD62); Leukocyte-Endothelial Cell Adhesion Molecule 3; CD62 Antigen-Like Family Member P; Granule Membrane Protein 140kDa; Granule Membrane Protein 140; GMP-140; LECAM3; PADGEM; GRMP; Selectin P (Granule Membrane Protein 140kD, Antigen CD62)
- Gene ID
- 6403
- UniProt ID
- P16109
- Long Name
- Selectin P
- Sequence Similarities
- Belongs to the selectin/LECAM family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn272, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LYAM3_HUMAN (2095)
Glycosylation from GlyGen 13 sites, 8 N-linked glycans (4 sites)
- Protein Refseq
- XP_005245492.1; XP_005245493.1; XP_005245495.1; XP_005245496.1; XP_005245497.1
- Function
- Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.
Mediates the interaction of activated endothelial cells or platelets with leukocytes.
The ligand recognized is sialyl-Lewis X.
Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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