AibGenesis™ Rabbit Anti-SOX2 Recombinant Antibody (VS-0426-FY920)
CAT#: VS-0426-FY920
VS-0426-FY920 is a Rabbit IgG targeting SOX2, developed through our AI-powered antibody discovery platform. Validated for WB, IHC, ICC, IF, and FC in Human, Mouse, and Rat, this affinity-purified antibody ensures reliable detection of this key pluripotency marker. It is indispensable for stem cell research, reprogramming studies, and developmental biology.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
Normal Tissue
Figure 3 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
Normal Tissue
Figure 4 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, NTERA-2, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
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| Sub Cat | Species Reactivity | Clone | Applications | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0426-FY176 | Human, Mouse, Rat | AibG-Rb-SO176 | WB, IHC, ICC, IF, FC | ||||||
| VS-0426-FY177 | Human | AibG-Rb-SO177 | WB, IHC, IP, IF-P |
More Infomation
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- SOX2
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Anophthalmia Syndrome
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target
- Alternative Names
- ANOP3; MCOPS3; Transcription factor SOX-2
- Gene ID
- 6657
- UniProt ID
- P48431
- Long Name
- SRY-Box 2
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.
- Protein Refseq
- NP_003097.1
- Function
- Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SOX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2438z | Mouse Anti-SOX2 Recombinant Antibody (clone 44A5) | WB, ELISA, IHC | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1906CT | Recombinant Mouse anti-Human SOX2 Monoclonal antibody (68DU34.4.5) | ELISA, ICC, IF, IHC-P, WB, sELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3377 | Hi-Affi™ Recombinant Rabbit Anti-SOX2 Monoclonal Antibody (DS3377AB) | ICC, IHC-P, WB, sELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2197-CN | Rabbit Anti-SOX2 Polyclonal Antibody (MRO-2197-CN) | WB, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0275 | APC-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0276 | PE-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0303 | APC-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0304 | PE-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0107-FY | Rabbit Anti-SOX2 Recombinant Antibody (clone AFY0078) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-108R | Mouse Anti-SOX2 Recombinant Antibody (ZG-108R) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-109R | Mouse Anti-SOX2 Recombinant Antibody (ZG-109R) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC574 | AbPlus™ Anti-SOX2 Magnetic Beads (VS-0724-YC574) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC90 | Mouse Anti-SOX2 Recombinant Antibody (VS-0924-YC90) - Cancer Stem Cell Marker | IHC, WB, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC91 | Rabbit Anti-SOX2 Antibody (VS-0924-YC91) - Cancer Stem Cell Marker | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY201 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (clone 245610) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY202 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (VS-0225-XY202) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2151 | Anti-SOX2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6822 | Anti-Mouse SOX2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6821 | Anti-Human SOX2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6823 | Anti-Rat SOX2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6824 | Anti-Canine SOX2 Immunohistochemistry Kit | IHC |
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