Mouse Anti-SOX2 Recombinant Antibody (VS3-FY2879)
CAT#: VS3-FY2879
This anti-SOX2 antibody is a mouse recombinant monoclonal antibody that has been specifically designed to target the human, mouse SOX2 protein. The calculated molecular weight of the protein is about 34.3 kDa. This monoclonal antibody is suitable for conducting research on Microphthalmia, Syndromic 3 and Septooptic Dysplasia.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
Normal Tissue
Figure 3 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
Normal Tissue
Figure 4 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, NTERA-2, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse SOX2
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot, Immunohistochemistry, Immunocytochemistry, Flow cytometry
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 34.3 kDa.
- Related Disease
- Microphthalmia, Syndromic 3 and Septooptic Dysplasia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/200-1/2000
Immunohistochemistry: 1/50-1/200
Immunocytochemistry: 1/10-1/50
Flow cytometry: 1/10-1/50
Target
- Alternative Names
- SRY-Box 2; SRY (Sex Determining Region Y)-Box 2; Sex Determining Region Y-Box 2; SRY-Related HMG-Box Gene 2; Transcription Factor SOX-2; Transcription Factor SOX2; SRY Box 2; MCOPS3; ANOP3
- Gene ID
- 6657
- UniProt ID
- P48431
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.
- Protein Refseq
- NP_003097.1
- Function
- Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SOX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2438z | Mouse Anti-SOX2 Recombinant Antibody (clone 44A5) | WB, ELISA, IHC | Mouse IgG2b, κ |
| ZG-0015U | Rabbit Anti-SOX2 Recombinant Antibody (clone 2E1) | ELISA, WB, IHC | Rabbit IgG |
| VS3-CJ83 | Mouse Anti-SOX2 Recombinant Antibody (VS3-CJ83) | WB, ELISA | Mouse IgG |
| VS3-WK1928 | Recombinant Rabbit Anti-SOX2 Capture Antibody (clone R85-4Y-7) | ELISA | Rabbit IgG |
| VS3-WK1929 | Recombinant Rabbit Anti-SOX2 Detection Antibody (clone R92-8O-9) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3377 | Hi-Affi™ Recombinant Rabbit Anti-SOX2 Monoclonal Antibody (DS3377AB) | ICC, IHC-P, WB, sELISA | IgG |
| MOR-0107-FY | Rabbit Anti-SOX2 Recombinant Antibody (clone AFY0078) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0275 | APC-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0276 | PE-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0303 | APC-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM | |
| MHC-CN0304 | PE-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC574 | AbPlus™ Anti-SOX2 Magnetic Beads (VS-0724-YC574) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC90 | Mouse Anti-SOX2 Recombinant Antibody (VS-0924-YC90) - Cancer Stem Cell Marker | IHC, WB, IF | Mouse IgG1 |
| VS-0924-YC91 | Rabbit Anti-SOX2 Antibody (VS-0924-YC91) - Cancer Stem Cell Marker | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY201 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (clone 245610) | FC | Mouse IgG2a |
| VS-0225-XY202 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (VS-0225-XY202) | FC | Mouse IgG1, kappa |
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