Recombinant Anti-SPP1 (Thrombin x MMP cleavage site) Biparatopic Antibody, Tandem scFv (mAb 4-4-2 x mAb 7-5-4) (CAT#: VS-0525-YC228)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Human SPP1

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• mAb 4-4-2

• Clone 2
• mAb 7-5-4

• Epitope 1
• On the ThrOpn cleavage site

• Epitope 2
• on the MMP cleavage site

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, WB

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Secreted Phosphoprotein 1

• Introduction
• The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

• Alternative Names
• SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

• Gene ID
• 6696

• UniProt ID
• A0A024RDE6

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