Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6990)
CAT#: TAB-0846CL-S(P)
This human antibody scFv Fragment can bind to osteopontin with high affinity and can neutralize both human and mouse osteopontin. It also may provide a method for treating various cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27540/1789_G12_1_cr59549927dd49e_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27541/1763_H3_6_selected.jpg
Normal Tissue
Figure 3 Kidney
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27541/64396_A_7_5_val_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27541/64396_A_8_3.jpg
Normal Tissue
Figure 5 Gallbladder
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27541/64396_A_6_4.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27541/64396_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118785-SPP1
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Specifications
- Host Species
- Human
- Derivation
- Phagemid library
- Type
- Human antibody
- Specificity
- Human
- Clone
- MOR-6990
- Applications
- ELISA
- Related Disease
- Breast cancer
Target
- Alternative Names
- SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
- Gene ID
- 6696
- UniProt ID
- A0A024RDE6
REVIEWS AND Q&AS
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Remarkable Specificity and Application
This SPP1 Antibody scFv Fragment has transformed our cancer research studies. Its specificity for osteopontin has led to groundbreaking insights into breast cancer metastasis. The robust results in ELISA have enhanced our experimental accuracy.
Reliable in Cancer Research
Utilizing this antibody in our lab, we found consistent performance and reliable specificity toward osteopontin. It's become integral to our studies on tumor growth, backed by excellent technical support from Creative Biolabs.
Excellent for Long-Term Projects
Its sustained supply and batch consistency have ensured continuity in our multi-phase research. The reliable binding to SPP1 makes it indispensable for our in-depth cancer studies.
Q&As
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How does the antibody achieve specificity in targeting SPP1?
A: The antibody's single-chain variable fragment (scFv) format ensures high specificity and affinity for SPP1, allowing it to bind precisely to osteopontin. This precision facilitates accurate detection and quantification in various experimental applications including ELISA.
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What is the primary application of the Anti-Human SPP1 Antibody scFv Fragment?
A: This antibody is designed to target and bind osteopontin (SPP1), a glycoprotein associated with bone mineralization and cell signaling. It is primarily used in cancer research to explore osteopontin's role in tumor growth and metastasis, making it invaluable for studies in oncology and immunology fields.
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Does Creative Biolabs offer technical support for this product?
A: Creative Biolabs provides robust technical and customer support, ensuring researchers receive guidance and insights on application techniques and troubleshooting, adding value beyond the product itself.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0846CL | Anti-Human SPP1 Recombinant Antibody (MOR-6990) | ELISA, Neut | Human antibody |
| TAB-0847CL | Anti-Human SPP1 Recombinant Antibody (MOR-6991) | ELISA | Human antibody |
| TAB-0848CL | Anti-Human SPP1 Recombinant Antibody (MOR-6993) | ELISA, FuncS, Neut | Human antibody |
| TAB-0847CL-S(P) | Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6991) | ELISA | Human antibody |
| TAB-0848CL-S(P) | Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6993) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0814MZ | Chicken Anti-Osteopontin Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3394 | Hi-Affi™ Recombinant Rabbit Anti-SPP1 Monoclonal Antibody (DS3394AB) | FC, ICC, IF, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-YC | Human Anti-SPP1 Recombinant Antibody (clone h2K1) | FuncS | Humanized IgG |
| MRO-2098-CN | Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2098-CN) | WB | Rabbit IgG |
| MRO-2099-CN | Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2099-CN) | WB, IHC, FC | Rabbit IgG |
| MRO-2100-CN | Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2100-CN) | IHC, ELISA | Rabbit IgG |
| MRO-2101-CN | Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2101-CN) | IF, IHC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-YC-S(P) | Human Anti-SPP1 Recombinant Antibody (clone h2K1); scFv Fragment | FuncS | Humanized scFv |
| HPAB-0069-YC-S(P) | Human Anti-SPP1 Recombinant Antibody (clone c2K1); scFv Fragment | FuncS | Mouse scFv |
| HPAB-0070-YC-S(P) | Human Anti-SPP1 Recombinant Antibody (clone R2K1v1.7); scFv Fragment | ELISA | Humanized scFv |
| HPAB-1363-FY-F(E) | Mouse Anti-SPP1 Recombinant Antibody (clone 1A12); scFv Fragment | WB, ELISA | Mouse scFv |
| HPAB-0569-YJ-S(P) | Human Anti-SPP1 Recombinant Antibody (clone OPN-3); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone h2K1); Fab Fragment | FuncS | Humanized Fab |
| HPAB-0069-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone c2K1); Fab Fragment | FuncS | Human Fab |
| HPAB-0070-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone R2K1v1.7); Fab Fragment | ELISA | Humanized Fab |
| HPAB-1363-FY-S(P) | Mouse Anti-SPP1 Recombinant Antibody (clone 1A12); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-0569-YJ-F(E) | Human Anti-SPP1 Recombinant Antibody (clone OPN-3); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY193 | Mouse Anti-SPP1 (clone 23C3) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6866 | Anti-SPP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6867 | Anti-Mouse SPP1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC228 | Recombinant Anti-SPP1 (Thrombin x MMP cleavage site) Biparatopic Antibody, Tandem scFv (mAb 4-4-2 x mAb 7-5-4) | ELISA, WB | Tandem scFv |
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